N,N-二甲基-溴乙酰胺合成路线 （共 13 条）
反应条件
triethylamine in dichloromethane Acylation;
参考文献
Cai, Lisheng; Han, Ying; Ren, Sumei; Huang, Liangfu
Tetrahedron, 2000 , vol. 56, # 42 p. 8253 - 8262
反应条件
in chloroform T=0 - 20°C; Methylation; 0.75 h;
参考文献
Jian, Zhigang; Filer, Crist; Kelly, Terence P.
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 8 p. 781 - 783
反应条件
1: monobromoacetic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 1 h; 2: dimethyl amine in tetrahydrofuran; dichloromethane 1 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; Bavetsias, Vassilios; Atrash, Butrus; Naud, Sébastien Gaston André; Sheldrake, Peter William; Blagg, Julian
Patent: US2013/345181 A1, 2013 ;
Location in patent: Paragraph 0707 ;
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
PFIZER LIMITED
Patent: WO2006/100588 A1, 2006 ;
Location in patent: Page/Page column 55 ;
WO 2006/100588 A1
反应条件
in tetrahydrofuran 1 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; BAVETSIAS, Vassilios; ATRASH, Butrus; NAUD, Sebastien Gaston Andre; SHELDRAKE, Peter William; BLAGG, Julian
Patent: WO2012/123745 A1, 2012 ;
Location in patent: Page/Page column 95 ;
WO 2012/123745 A1
反应条件
potassium phosphate; hydroquinone; tri-cyclo-hexyl-phosphine; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=70°C;
参考文献
Lu, Ting-Yi; Xue, Cuihua; Luo, Fen-Tair
Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1587 - 1590
反应条件
potassium carbonate in acetone Alkylation; Heating;
参考文献
Cai, Lisheng; Han, Ying; Ren, Sumei; Huang, Liangfu
Tetrahedron, 2000 , vol. 56, # 42 p. 8253 - 8262
反应条件
triethylamine in water; acetonitrile
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US4021472 A1, 1977 ;
反应条件
(i) NaH, DMF, (ii) /BRN= 1743734/; Multistep reaction;
参考文献
Islip; Closier; Neville
Journal of Medicinal Chemistry, 1974 , vol. 17, # 2 p. 207 - 209
反应条件
in tetrahydrofuran; acetonitrile T=20°C; 4 h;
参考文献
Pospisil, Jiri; Potacek, Milan
Tetrahedron, 2007 , vol. 63, # 2 p. 337 - 346
