2-[(4-氯苯基)氨基]乙酸合成路线 （共 17 条）
反应条件
sulfuric acid in benzene 14 h; Heating;
参考文献
Hiremath; Biradar; Kudari
Journal of the Indian Chemical Society, 1984 , vol. 61, # 1 p. 74 - 76
反应条件
1: sulphuric acid / benzene / 14 h / Heating 2: hydrazinehydrate / H2O; ethanol / 5 h / Heating View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 61, # 1 p. 74 - 76
反应条件
ammonium hydroxide in methanol; dichloromethane; sulfuric acid; water
参考文献
Glaxo Laboratories Limited
Patent: US3976680 A1, 1976 ;
反应条件
thionyl chloride T=0°C; 3 h; Inert atmosphere;
参考文献
Broeders, Fabienne; Defrere, Laurent; Deltent, Marie-France; Driessens, Frank; Gilson, Frederic; Grooters, Luc; Ikonomakos, Xavier; Limauge, Frederic; Sergeef, Emmanuel; Verstraeten, Natacha
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 442 - 449
反应条件
tetrachlorosilane; silica gel; sodium nitrite in dichloromethane T=0 - 5°C; 2.3 h;
参考文献
Azarifar, Davood; Bosra, Hassan Ghasemnejad; Zolfigol, Mohammad-Ali; Tajbaksh, Mahmood
Heterocycles, 2006 , vol. 68, # 1 p. 175 - 181
反应条件
trifluoroacetic anhydride in toluene
参考文献
American Cyanamid Company
Patent: US5492925 A1, 1996 ;
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran
T=0 - 20°C;
2: With hydrogenchloride in tetrahydrofuran; water
T=20°C; pH=3 - 4;
参考文献
Fang, Yuesi; Wu, Chunrui; Larock, Richard C.; Shi, Feng
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8840 - 8851
反应条件
1: With silica gel
T=20°C; 0.08 h; microwave irradiation;
2: With sodium hydroxide in ethanol
0.166667 h; Heating;
参考文献
Azarifar, Davood; Bosra, Hassan Ghasemnejad; Zolfigol, Mohammad-Ali; Tajbaksh, Mahmood
Heterocycles, 2006 , vol. 68, # 1 p. 175 - 181
反应条件
platinum on activated charcoal; hydrogen; acetic acid in tetrahydrofuran
T=20°C; 3 h;
参考文献
Broeders, Fabienne; Defrere, Laurent; Deltent, Marie-France; Driessens, Frank; Gilson, Frederic; Grooters, Luc; Ikonomakos, Xavier; Limauge, Frederic; Sergeef, Emmanuel; Verstraeten, Natacha
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 442 - 449
反应条件
1: 2-bromo acetyl bromide With poly(ethylene glycol) 3400; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C;
2: 4-chloro-aniline in dichloromethane
T=20°C;
3: With sodium hydroxide in water
T=60°C;
参考文献
Hu, Chunling; Chen, Zuxing; Yang, Guichun
Synthetic Communications, 2004 , vol. 34, # 2 p. 219 - 224
