2-(1-乙氧基亚乙基)丙二腈合成路线

参考文献

ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC.; ADDEX PHARMA S.A.; CID-NUNEZ, Jose, Maria; TRABANCO-SUAREZ, Andres, Avelino; MACDONALD, Gregor, James
Patent: WO2010/60589 A1, 2010 ;
Location in patent: Page/Page column 28 ;
WO 2010/060589 A1

619-27-23-硝基苯肼+

5417-82-32-(1-乙氧基亚乙基)丙二腈

107842-58-05-氨基-4-氰基-3-甲基-1-(3-硝基苯基)吡唑

参考文献

Mizuhara, Tsukasa; Kato, Takayuki; Hirai, Atsushi; Kurihara, Hideki; Shimada, Yasuhiro; Taniguchi, Masahiko; Maeta, Hideki; Togami, Hiroaki; Shimura, Kazuya; Matsuoka, Masao; Okazaki, Shiho; Takeuchi, Tomoki; Ohno, Hiroaki; Oishi, Shinya; Fujii, Nobutaka
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4557 - 4561

5446-18-42,4-二氯苯肼盐酸盐+

5417-82-32-(1-乙氧基亚乙基)丙二腈

58791-83-65-氨基-4-氰基-1-(2,4-二氯苯基)-3-甲基-1H-吡唑

参考文献

Faria, Jessica V.; Dos Santos, Mauricio S.; Bernardino, Alice M.R.; Becker, Klaus M.; Machado, Gerzia M.C.; Rodrigues, Raquel F.; Canto-Cavalheiro, Marilene M.; Leon, Leonor L.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6310 - 6312

60-34-4甲基肼+

5417-82-32-(1-乙氧基亚乙基)丙二腈

54820-92-75 -氨基- 1,3-二甲基-4 -腈-1H -吡唑

参考文献

TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 45; 46 ;

5417-82-32-(1-乙氧基亚乙基)丙二腈

35261-06-45-氨基-3-甲基-4-异恶唑甲酰胺

参考文献

Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120

1073-70-7对氯苯肼盐酸盐+

5417-82-32-(1-乙氧基亚乙基)丙二腈

58791-82-55-氨基-1-(4-氯l苯基)-3-甲基-1H-吡唑-4-甲腈

参考文献

Faria, Jessica V.; Dos Santos, Mauricio S.; Bernardino, Alice M.R.; Becker, Klaus M.; Machado, Gerzia M.C.; Rodrigues, Raquel F.; Canto-Cavalheiro, Marilene M.; Leon, Leonor L.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6310 - 6312

5417-82-32-(1-乙氧基亚乙基)丙二腈

35261-01-95-氨基-3-甲基-4-异恶唑甲腈

参考文献

TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 29 ;

5417-82-32-(1-乙氧基亚乙基)丙二腈

41808-35-93-甲基-4-氰基-5-氨基异噻唑

参考文献

INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;

823-85-84-氟苯肼盐酸盐+

5417-82-32-(1-乙氧基亚乙基)丙二腈

51516-82-65-氨基-1-(4-氟苯基)-3-甲基-1H-吡唑-3-甲腈

参考文献

Faria, Jessica V.; Dos Santos, Mauricio S.; Bernardino, Alice M.R.; Becker, Klaus M.; Machado, Gerzia M.C.; Rodrigues, Raquel F.; Canto-Cavalheiro, Marilene M.; Leon, Leonor L.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6310 - 6312

4637-24-5N,N-二甲基甲酰胺二甲基缩醛+

5417-82-32-(1-乙氧基亚乙基)丙二腈

98645-43-32-氯-3-氰基-4-甲氧基吡啶+

98645-45-52-氯-4-乙氧基烟腈

参考文献

Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388