(2-氧代-吡咯烷-1-基)-乙酸合成路线 （共 17 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=23°C; 3 h;
参考文献
VICURON PHARMACEUTICALS INC.
Patent: US2006/211603 A1, 2006 ;
Location in patent: Page/Page column 76 ;
反应条件
hydrogenchloride; water in acetic acid T=20°C; 2 h;
参考文献
H. LUNDBECK A/S
Patent: US2009/143402 A1, 2009 ;
Location in patent: Page/Page column 51 ;
US 20090143402 A1
反应条件
sodium hydroxide in tetrahydrofuran T=20°C; Hydrolysis; 24 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 8 p. 1637 - 1646
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=50°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=4;
参考文献
WO2006/138350 A2, ;
Page/Page column 79 ;
WO 2006/138350 A2
反应条件
sodium hydride in toluene T=60°C; 6 h;
参考文献
Dalla Croce, Piero; La Rosa, Concetta
Heterocycles, 2001 , vol. 55, # 10 p. 1843 - 1857
反应条件
sodium hydride in tetrahydrofuran 12 h;
参考文献
Garst, Michael E.; Bonfiglio, John N.; Grudoski, David A.; Marks, Jeffrey
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2307 - 2315
反应条件
1: 1M aq. HCl / 2 h / 50 °C 2: H2 / 5percent Ru/C / H2O / 24 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 75, # 3 p. 892 - 900
反应条件
dicobalt octacarbonyl T=120°C; P=155144 Torr;
参考文献
Journal of Organometallic Chemistry, , vol. 417, # 1/2 p. 99 - 110
反应条件
hydrogen; Ru-carbon in water 24 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Helvetica Chimica Acta, , vol. 75, # 3 p. 892 - 900
反应条件
hydrogen tetrachloroaurate(III); water T=100°C; 0.25 h;
参考文献
Chemistry - A European Journal, , vol. 15, # 47 p. 13181 - 13187
