(联苯-2-氧基)-乙酸合成路线 （共 12 条）
反应条件
1: With triethylamine in N,N-dimethyl-formamide; toluene Curtius rearrangement; 3 h; Heating; 2: With potassium hydroxide; glycerol in ethanol; N,N-dimethyl-formamide; toluene 2 h; Heating; Further stages.;
参考文献
Spurg, Anke; Waldvogel, Siegfried R.
European Journal of Organic Chemistry, 2008 , # 2 p. 337 - 342
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate
8 h;
参考文献
VICURON PHARMACEUTICALS INC.
Patent: US2006/211603 A1, 2006 ;
Location in patent: Page/Page column 40; 58 ;
反应条件
1: 2-hydroxybiphenyl With sodium hydride in tetrahydrofuran; mineral oil
T=20°C; 0.75 h; Inert atmosphere;
2: monobromoacetic acid in tetrahydrofuran; mineral oil
T=20°C; Inert atmosphere;
参考文献
Pinter, Aron; Klussmann, Martin
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 701 - 711
反应条件
lithium hydroxide hydrate in methanol; water
参考文献
Manley, David W.; McBurney, Roy T.; Miller, Phillip; Walton, John C.; Mills, Andrew; O'Rourke, Christopher
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1386 - 1398
反应条件
in 1,8-diazabicyclo[5.4.0]undec-7-ene; acetonitrile
参考文献
Japan Energy Corporation
Patent: US6313094 B1, 2001 ;
US 6313094 B1
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene; ethanol / |Reflux
3: acetyl chloride / methanol
4: potassium carbonate / tetrahydrofuran / |Reflux
5: lithium hydroxide hydrate / water; methanol
View Scheme
参考文献
Manley, David W.; McBurney, Roy T.; Miller, Phillip; Walton, John C.; Mills, Andrew; O'Rourke, Christopher
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1386 - 1398
反应条件
1: potassium carbonate / tetrahydrofuran / |Reflux
2: lithium hydroxide hydrate / water; methanol
View Scheme
参考文献
Manley, David W.; McBurney, Roy T.; Miller, Phillip; Walton, John C.; Mills, Andrew; O'Rourke, Christopher
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1386 - 1398
反应条件
1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene; ethanol / |Reflux
2: acetyl chloride / methanol
3: potassium carbonate / tetrahydrofuran / |Reflux
4: lithium hydroxide hydrate / water; methanol
View Scheme
参考文献
Manley, David W.; McBurney, Roy T.; Miller, Phillip; Walton, John C.; Mills, Andrew; O'Rourke, Christopher
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1386 - 1398
反应条件
lithium hydroxide hydrate in ethanol; water
RefluxInert atmosphere;
参考文献
Rueda-Becerril, Montserrat; Mahe, Olivier; Drouin, Myriam; Majewski, Marek B.; West, Julian G.; Wolf, Michael O.; Sammis, Glenn M.; Paquin, Jean-Francois
Journal of the American Chemical Society, 2014 , vol. 136, # 6 p. 2637 - 2641
反应条件
1: palladium 10 on activated carbon; potassium hydroxide / water / 0.33 h / 120 °C / |Microwave irradiation; |Inert atmosphere
2: caesium carbonate / acetone / |Reflux; |Inert atmosphere
3: lithium hydroxide hydrate / water; ethanol / |Reflux; |Inert atmosphere
View Scheme
参考文献
Rueda-Becerril, Montserrat; Mahe, Olivier; Drouin, Myriam; Majewski, Marek B.; West, Julian G.; Wolf, Michael O.; Sammis, Glenn M.; Paquin, Jean-Francois
Journal of the American Chemical Society, 2014 , vol. 136, # 6 p. 2637 - 2641
