2-氰基-4,4-二乙氧基丁酸乙酯合成路线 （共 26 条）
反应条件
potassium carbonate; sodium iodide T=145°C; 4.5 h; Inert atmosphere;
参考文献
Kim, Jiae; Wang, Ligong; Li, Yongfeng; Becnel, Kimberlynne D.; Frey, Kathleen M.; Garforth, Scott J.; Prasad, Vinayaka R.; Schinazi, Raymond F.; Liotta, Dennis C.; Anderson, Karen S.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4064 - 4067
反应条件
1: BrCH(CN)CO2Et; ethyl vinyl ether With MeOAMVN in dichloromethane T=25°C; Addition; 2 h; 2: ethanol in dichloromethane T=25°C; ethanolysis; 0.5 h;
参考文献
Kita, Yasuyuki; Sano, Atsunori; Yamaguchi, Takahiro; Oka, Masahisa; Gotanda, Kentoku; Matsugi, Masato
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 675 - 678
反应条件
sodium methylate; sodium iodide in ethanol; N,N-dimethyl-formamide T=95°C; 4 h;
参考文献
Gangjee, Aleem; Wang, Ying; Queener, Sherry F.; Kisliuk, Roy L.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1523 - 1531
反应条件
1: 64 percent / NaOEt 2: 92 percent / aq. HCl 3: 81 percent / H2 / Raney Ni 4: 66 percent / POCl3 View Scheme
参考文献
Tsytovich, A. V.; Shamshin, D. V.; Burkovskii, V. B.; Shvets, V. I.
Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 11 p. 756 - 761
Bioorganicheskaya Khimiya, 1995 , vol. 21, # 11 p. 874 - 880
反应条件
1: 64 percent / NaOEt 2: 92 percent / aq. HCl 3: 81 percent / H2 / Raney Ni View Scheme
参考文献
Tsytovich, A. V.; Shamshin, D. V.; Burkovskii, V. B.; Shvets, V. I.
Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 11 p. 756 - 761
Bioorganicheskaya Khimiya, 1995 , vol. 21, # 11 p. 874 - 880
反应条件
1.1: sodium ethanolate / ethanol / 0.08 h / 5 - 10 °C 1.2: 80 °C 1.3: 20 °C 2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 70 - 80 °C View Scheme
参考文献
Xie, Hui; Zeng, Lili; Zeng, Shaogao; Lu, Xin; Zhang, Guicheng; Zhao, Xin; Cheng, Na; Tu, Zhengchao; Li, Zhiyuan; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Huang, Min; Zhao, Junling; Hu, Wenhui
European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 205 - 212
反应条件
1: urea With sodium ethanolate in ethanol T=5 - 10°C; 0.0833333 h; 2: 2-cyano-4,4-diethoxy-butyric acid ethyl ester in ethanol T=80°C; 3: With hydrogenchloride in water T=20°C;
参考文献
Xie, Hui; Zeng, Lili; Zeng, Shaogao; Lu, Xin; Zhang, Guicheng; Zhao, Xin; Cheng, Na; Tu, Zhengchao; Li, Zhiyuan; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Huang, Min; Zhao, Junling; Hu, Wenhui
European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 205 - 212
反应条件
1: 82 percent / EtONa / ethanol / 6 h / Heating 2: 88 percent / 0.2N aq. HCl / 1 h / 20 °C 3: 50 percent / POCl3 / 6 h / Heating View Scheme
参考文献
Russian Journal of Bioorganic Chemistry, , vol. 21, # 11 p. 756 - 761
Bioorganicheskaya Khimiya, , vol. 21, # 11 p. 874 - 880
反应条件
1: 64 percent / NaOEt 2: 92 percent / aq. HCl 3: 81 percent / H2 / Raney Ni 4: 66 percent / POCl3 5: 84 percent / H2 / Pd/C View Scheme
参考文献
Reigan, Philip; Gbaj, Abdul; Chinje, Edwin; Stratford, Ian J.; Douglas, Kenneth T.; Freeman, Sally
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5247 - 5250
反应条件
1: 46 percent / CH3ONa / methanol / 4 h / Heating 2: 82 percent / POCl3, N,N-dimethylaniline / 5 h / Heating View Scheme
参考文献
Seela; Liman
1984 , vol. 1984, # 2 p. 273 - 282
