α-乙酰基-γ-丁内酯合成路线 （共 116 条）
反应条件
T=100°C; P=1064 Torr; 0.5 h; various molar ratio of the reagents, other temp., other pressure, other time; Product distribution;
参考文献
Lipkin, M. A.; Markevich, V. S.; Kirsanov, A. T.; Yurkevich, A. M.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 12 p. 911 - 915
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 12 p. 1465 - 1469
参考文献
Knunjanz; Tschelinzew; Ossetrowa
Doklady Akademii Nauk SSSR, 1934 , p. I 314
Chem. Zentralbl., 1934 , vol. 105, # II p. 2381
参考文献
Birkofer; Storch
Chemische Berichte, 1954 , vol. 87, p. 571,576
反应条件
1: 68 percent / HI / H2O 2: 70 percent / toluene-p-sulphonic acid / toluene / 24 h / Heating 3: 2.) 30percent sodium hydroxide / 1.) toluene, reflux, 2 d; 2.) water, reflux, 2 h 4: 41 percent / butyl-lithium / tetrahydrofuran / 1.) -78 degC, 4 h, 2.) -78 degC to R. T. 5: 85 percent / m-chloroperbenzoic acid / CHCl3 / 2 h / Ambient temperature 6: 95 percent / toluene / 6 h / 100 °C 7: 75 percent / 1.) butyl-lithium, 2.) benzaldehyde, H2O / tetrahydrofuran / 1.) -60 degC, 2.) -78 degC to R. T. View Scheme
参考文献
Cornish Christopher A.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2585 - 2598
反应条件
1: toluene-4-sulfonic acid 2: trichlorophosphate View Scheme
参考文献
Pacquelet, Sandrine; Blache, Yves; Kimny, Tan; Dubois, Marie-Aleth Lacaille; Desbois, Nicolas
Synthetic Communications, 2013 , vol. 43, # 8 p. 1092 - 1100
反应条件
hydrogen bromide in toluene T=80°C; 14 h;
参考文献
Yu, Fanglei; Miller, David J.; Allemann, Rudolf K.
Chemical Communications, 2007 , # 40 p. 4155 - 4157
反应条件
trichlorophosphate in toluene 6 h; Heating / reflux;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2004/35573 A1, 2004 ;
Location in patent: Page 8-9 ;
反应条件
1: toluene-4-sulfonic acid / toluene / Reflux 2: trichlorophosphate / 1 h / Reflux View Scheme
参考文献
Mallesha, Lingappa; Mohana, Kikkeri N.; Veeresh, Bantal; Alvala, Ravi; Mallika, Alvala
Archives of Pharmacal Research, 2012 , vol. 35, # 1 p. 51 - 57
反应条件
Na2B4O7; Oxonereg;; sodium hydroxide; borax decahydrate in water T=20 - 25°C; Oxidation; hydroxylation; pH=8.5; 3 h;
参考文献
Ragoussis, Valentine; Lagouvardos, Dimitrios J.; Ragoussis, Nikitas
Synthetic Communications, 1998 , vol. 28, # 22 p. 4273 - 4278
反应条件
1: 1) NaH / 1) THF, 0 deg C, 30 min, 2) THF, 0 deg C, 5 min 2: 24 percent / 30percent H2O2 / CH2Cl2 / 1) 0 deg C, 1 h, 2) 25 deg C, 4 h 3: 95 percent / 425 °C / 0.01 Torr 4: 1) (+)-β-chlorodiisopinocamphenylborane, 2) diethanolamine / 1) THF, -30 deg C, 5 days, 2) Et2O, 2 h 5: 48 percent / mercury(II) acetate / 24 h / 135 - 140 °C 6: H2 / 10percent Pd/C / ethanol / 760 Torr View Scheme
参考文献
Horne; Fugmann; Yakushijin; Buchi
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 62 - 64
