4-羟基-4-苯基-环己酮合成路线 （共 11 条）
反应条件
1: 74 percent / 30percent aq. H2SO4 / diethyl ether / 1 h / 0 °C 2: 12 percent / 1) SOCl2, 2) NaOH / 1) pyridine, 0 deg C, 1 h, 2) ether, MeOH, r.t., 1 h View Scheme
参考文献
Eberbach, Wolfgang; Carre, Jean Claude
Chemische Berichte, 1981 , vol. 114, # 3 p. 1027 - 1047
参考文献
Mattson, Ronald J; Catt, John D; Sloan, Charles P; Gao; Carter, Richard B; Gentile, Anthony; Mahle, Cathy D; Matos, F Fatima; McGovern, Rachel; VanderMaelen, Cam P; Yocca, Frank D
Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 285 - 288
反应条件
in diethyl ether; cyclohexane
T=-78°C; 2 h;
参考文献
Kobayashi, Kazuhiro; Sasaki, Akiyoshi; Kanno, Yoshikazu; Suginome, Hiroshi
Tetrahedron, 1991 , vol. 47, # 35 p. 7245 - 7258
参考文献
The Upjohn Company
Patent: US3960961 A1, 1976 ;
反应条件
1: 57 percent / diethyl ether / 1 h / 0 °C
2: 85 percent / Triton B / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Singh, Chandan; Malik, Heetika
Organic Letters, 2005 , vol. 7, # 25 p. 5673 - 5676
反应条件
1: tetrahydrofuran
2: aq. HCl
View Scheme
参考文献
Mattson, Ronald J; Catt, John D; Sloan, Charles P; Gao; Carter, Richard B; Gentile, Anthony; Mahle, Cathy D; Matos, F Fatima; McGovern, Rachel; VanderMaelen, Cam P; Yocca, Frank D
Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 285 - 288
反应条件
dipotassium hydrogenphosphate in water; dimethyl sulfoxide
pH=7; 72 h; Microbiological reaction;
参考文献
Bright, Tara V.; Dalton, Fay; Elder, Victoria L.; Murphy, Cormac D.; O'Connor, Neil K.; Sandford, Graham
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1135 - 1142
反应条件
1: tetrahydrofuran / 2 h / 10 - 20 °C
2: hydrogenchloride; water / tetrahydrofuran / 20 °C
View Scheme
参考文献
PFIZER LIMITED; BURGESS, Gary
Patent: WO2012/114223 A1, 2012 ;
WO 2012/114223 A1
参考文献
Carenini,G. et al.
Farmaco, Edizione Scientifica, 1973 , vol. 28, p. 896 - 906
反应条件
iodine; mercury(II) oxide in benzene
3.5 h; Ambient temperatureIrradiation;
参考文献
Kobayashi, Kazuhiro; Sasaki, Akiyoshi; Kanno, Yoshikazu; Suginome, Hiroshi
Tetrahedron, 1991 , vol. 47, # 35 p. 7245 - 7258
