1-(3-溴丙氧基)-2-氯苯合成路线 （共 8 条）
反应条件
1: 2-chlorophenol With sodium hydroxide in water 2: 1,3-dibromo-propane in water Reflux;
参考文献
Capuano, Ben; Crosby, Ian T.; McRobb, Fiona M.; Podloucka, Anna; Taylor, David A.; Vom, Amelia; Yuriev, Elizabeth
Australian Journal of Chemistry, 2010 , vol. 63, # 1 p. 116 - 124
反应条件
triphenylphosphine in tetrahydrofuran; ethyl acetate; acetonitrile
参考文献
H. Lundbeck A/S
Patent: US2003/50307 A1, 2003 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in toluene 24 h; Heating; Yield given. Yields of byproduct given;
参考文献
Reinholz; Becker; Hagenbruch; Schafer; Schmitt
Synthesis, 1990 , # 11 p. 1069 - 1071
反应条件
in toluene T=85°C; 2 h;
参考文献
Capuano, Ben; Crosby, Ian T.; McRobb, Fiona M.; Podloucka, Anna; Taylor, David A.; Vom, Amelia; Yuriev, Elizabeth
Australian Journal of Chemistry, 2010 , vol. 63, # 1 p. 116 - 124
反应条件
1.1: NaN3 / dimethylformamide / 2.5 h / 110 °C
2.1: PPh3 / tetrahydrofuran / 15 h / 20 °C
2.2: 86 percent / H2O / tetrahydrofuran / 3 h / 20 °C
3.1: N,N'-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene*HCl; NaH; t-BuOH / Pd(OAc)2 / dioxane / 8 h
View Scheme
参考文献
Omar-Amrani, Rafik; Schneider, Raphael; Fort, Yves
Synthesis, 2004 , # 15 p. 2527 - 2534
反应条件
ueber <3-(2-Chlor-phenoxy)-propyl>-malonsaeure-diaethylester;
参考文献
Fawcett et al.
Proceedings of the Royal Society of London, Series B: Biological Sciences, 1959 , vol. 150, p. 95,100
反应条件
in ethanol
T=20°C; 12 h;
参考文献
Sheng, Chunquan; Wang, Wenya; Che, Xiaoying; Dong, Guoqiang; Wang, Shengzheng; Ji, Haitao; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian
ChemMedChem, 2010 , vol. 5, # 3 p. 390 - 397
反应条件
1.1: NaN3 / dimethylformamide / 2.5 h / 110 °C
2.1: PPh3 / tetrahydrofuran / 15 h / 20 °C
2.2: 86 percent / H2O / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Omar-Amrani, Rafik; Schneider, Raphael; Fort, Yves
Synthesis, 2004 , # 15 p. 2527 - 2534
