1-氯-3-甲基-2-丁烯合成路线 （共 287 条）
反应条件
1: 96.4 percent / TEBA / 4.5 h / 95 - 105 °C 2: 95 percent / aq. NaOH / 2.5 h / 100 °C 3: 95 percent / MnO2 / petroleum ether / 7 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 31, # 2 p. 219 - 224
参考文献
Kuraray Co., Ltd.
Patent: US4122119 A1, 1978 ;
反应条件
sodium hydroxide; triethylamine T=60°C; 4 h;
参考文献
Yufit, S. S.; Esikova, I. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 9 p. 1637 - 1642
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , vol. 30, # 9 p. 1996 - 2001
反应条件
potassium hydroxide; 3-chloro-3-methyl-1-butene; N-benzyl-N,N,N-triethylammonium chloride in benzene Yield given;
参考文献
Esikova, I. A.; Yufit, S. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 3 p. 328 - 335
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 3 p. 507 - 514
反应条件
3-chloro-3-methyl-1-butene; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in benzene T=40°C; effect of various condensing system, effect of concentration aq. KOH on the initial rates of formation, on the accumulation of the products in the organic phase, in the aqueous phase; Mechanism;
参考文献
Yufit, S. S.; Esikova, I. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 3 p. 340 - 343
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 3 p. 519 - 522
反应条件
potassium hydroxide; 3-chloro-3-methyl-1-butene in benzene T=40°C; effect of the amount of 50percent aq. KOH on the initial rates;
参考文献
Esikova, I. A.; Yufit, S. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 3 p. 328 - 335
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 3 p. 507 - 514
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in benzene T=40°C; other reagent; MechanismProduct distribution;
参考文献
Yufit, S. S.; Esikova, I. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 9 p. 1637 - 1642
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , vol. 30, # 9 p. 1996 - 2001
反应条件
potassium hydroxide; 3-chloro-3-methyl-1-butene in benzene T=40°C; further reagents;
参考文献
Esikova, I. A.; Yufit, S. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 3 p. 328 - 335
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 3 p. 507 - 514
反应条件
potassium carbonate in acetone T=20°C;
参考文献
Liu, Zhiguo; Tang, Longguang; Zou, Peng; Zhang, Yali; Wang, Zhe; Fang, Qilu; Jiang, Lili; Chen, Gaozhi; Xu, Zheng; Zhang, Huajie; Liang, Guang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 671 - 682
反应条件
1: 96 percent / 1.) NaH / dimethylformamide / 10 °C / 1.) 15 min, 2.) 15 min 2: 96 percent / 1.) n-BuLi / tetrahydrofuran; hexane / 0.5 h / -70 °C 3: 1.) Li, NH3, 2.) FeCl3, air / 1.) Et2O, -40 deg C, 3 h, 2.) AcOH, 25 deg C View Scheme
参考文献
Veselovskii, A. B.; Moiseenkov, A. M.; Filippova, T. M.; Obol'nikova, E. A.; Samokhvalov, G. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, # 3 p. 594 - 599
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 3 p. 695 - 701
