8-氯-3,7-二氢-1,3,7-三甲基-1H-嘌呤-2,6-二酮合成路线 （共 61 条）
参考文献
Balaban
Journal of the Chemical Society, 1926 , p. 572
Full Text Show Details
Aiello
Biochemische Zeitschrift, 1921 , vol. 124, p. 200
参考文献
Fischer,E.
Justus Liebigs Annalen der Chemie, 1882 , vol. 215, p. 267
Chemische Berichte, 1895 , vol. 28, p. 2485
参考文献
Huston; Allen
Journal of the American Chemical Society, 1934 , vol. 56, p. 1358
反应条件
1: phenylmethanethiol With sodium hydroxide in ethanol; water Cooling with ice; 2: 8-Chlorocaffeine in ethanol; water 1 h; Reflux;
参考文献
Booysen, Hermanus P.; Moraal, Christina; Terre'Blanche, Gisella; Petzer, Anel; Bergh, Jacobus J.; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7507 - 7518
反应条件
iodine; chlorine; 1,2-dichloro-benzene Erhitzen des Reaktionsprodukts mit wss.Essigsaeure und Behandeln des erhaltenen 8-Chlor-1-methyl-3,7-dihydro-purin-2,6-dions (C6H5ClN4O2) mit HI und PH4I;
参考文献
Mann; Porter
Journal of the Chemical Society, 1945 , p. 751,757
反应条件
potassium arsenite; ethanol T=140 - 180°C;
参考文献
Yoshitomi
Yakugaku Zasshi, 1929 , vol. 49, p. 46
Chem. Zentralbl., 1929 , vol. 100, # I p. 2991
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Yoshitomi; Miyanaga; Nagae
Yakugaku Zasshi, 1926 , p. 5
Chem. Zentralbl., 1926 , vol. 97, # II p. 2726
参考文献
Balaban
Journal of the Chemical Society, 1926 , p. 572
反应条件
1: toluene 2: ethanolic sodium ethylate 3: aqueous HCl 4: 150 °C View Scheme
参考文献
Golowtschinskaja
Sb. Statei Obshch. Khim., 1953 , p. 702,708, 709
Chem.Abstr., 1955 , p. 1070
反应条件
1: 3-methyl-1-butanol With sodium T=20°C; 2: 8-Chlorocaffeine T=150°C; 6 h;
参考文献
Strydom, Belinda; Bergh, Jacobus J.; Petzer, Jacobus P.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3474 - 3485
参考文献
Magnanini
Chemische Berichte, 25 Ref. <1892>, 45
