2-甲基-3-硝基苯甲醚合成路线 （共 34 条）
反应条件
1: EtOK / ethanol / Heating 2: aq. HCl 3: FeSO4/NH3 5: NaH / dimethylsulfoxide View Scheme
参考文献
Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
反应条件
potassium permanganate; water
参考文献
Doyle,F.P. et al.
Journal of the Chemical Society, 1963 , p. 497 - 506
反应条件
1: tin; aqueous hydrochloric acid View Scheme
参考文献
Jones; Robertson
Journal of the Chemical Society, 1930 , p. 1699,1707
反应条件
1: H2 / PtO2 / propan-2-ol / 2327.2 Torr 2: 1) conc. H2SO4, NaNO2, 2) CuBr, HBr / 1) H2O, 0-10 deg C, 2) H2O View Scheme
参考文献
Young, David C.; Vouros, Paul; Holick, Michael F.; Higuchi, Tetsuo
Analytical Chemistry, 1992 , vol. 64, # 8 p. 837 - 842
反应条件
1: 83 percent / CuI; DMF / 3 h / 180 °C / 6000.6 - 7500.75 Torr / microwave irradiation 2: 63 percent / H2 / Pd/C / methanol; CH2Cl2 / 20 °C View Scheme
参考文献
Lloyd, David H.; Nichols, David E.
Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4561 - 4562
反应条件
iron; silica gel 1) 120 deg C, 4 h, under vacuum 2) 1 h reflux in toluene-acetic acid; Yield given. Multistep reaction;
参考文献
Kawase, Masami; Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1499 - 1501
反应条件
pyrrolidine; hydrazine hydrate; nickel 1.) DMF, 125 deg C, 3 h; 2.) methanol, 50-60 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Repke; Ferguson
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 4 p. 845 - 848
反应条件
in tetrahydrofuran T=-40°C; 0.5 h;
参考文献
H. LUNDBECK A/S
Patent: WO2009/120655 A1, 2009 ;
Location in patent: Page/Page column 38 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane Heating;
参考文献
Rzasa, Robert M.; Kaller, Matthew R.; Liu, Gang; Magal, Ella; Nguyen, Thomas T.; Osslund, Timothy D.; Powers, David; Santora, Vincent J.; Viswanadhan, Vellarkad N.; Wang, Hui-Ling; Xiong, Xiaoling; Zhong, Wenge; Norman, Mark H.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 20 p. 6574 - 6595
反应条件
1: 1.) pyrrolidine; 2.) 85percent N2H4 / 2.) Raney Ni / 1.) DMF, 125 deg C, 3 h; 2.) methanol, 50-60 deg C, 3 h 2: 56 percent / trifluoroacetic acid / 0.5 h / Ambient temperature 3: 65 percent / LiAlH4; HCl / tetrahydrofuran / 0.25 h / Heating 4: 49 percent / H2O / 1 h / Heating View Scheme
参考文献
Repke; Ferguson
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 4 p. 845 - 848
