2-环戊基-2-羟基苯乙酸合成路线 （共 13 条）
反应条件
in diethyl ether T=0 - 20°C; 24.5 h;
参考文献
Wu; Mori; Buchwald; Bodor, Nicholas
Pharmazie, 2008 , vol. 63, # 3 p. 200 - 209
反应条件
sodium hydroxide in methanol; water T=20°C; Inert atmosphere;
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
potassium hydroxide in methanol T=20°C;
参考文献
Kumar, Naresh; Kaur, Kirandeep; Aeron, Shelly; Dharmarajan, Sankaranarayanan; Silamkoti, Arun D.V.; Mehta, Anita; Gupta, Suman; Chugh, Anita; Gupta, Jang B.; Salman, Mohammad; Palle, Venkata P.; Cliffe, Ian A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5256 - 5260
反应条件
1: tetrahydrofuran / 0 - 20 °C 2: KOH / methanol / 20 °C View Scheme
参考文献
Kumar, Naresh; Kaur, Kirandeep; Aeron, Shelly; Dharmarajan, Sankaranarayanan; Silamkoti, Arun D.V.; Mehta, Anita; Gupta, Suman; Chugh, Anita; Gupta, Jang B.; Salman, Mohammad; Palle, Venkata P.; Cliffe, Ian A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5256 - 5260
反应条件
1: tetrahydrofuran / 0 - 20 °C 2: KOH / methanol / 20 °C View Scheme
参考文献
Kumar, Naresh; Kaur, Kirandeep; Aeron, Shelly; Dharmarajan, Sankaranarayanan; Silamkoti, Arun D.V.; Mehta, Anita; Gupta, Suman; Chugh, Anita; Gupta, Jang B.; Salman, Mohammad; Palle, Venkata P.; Cliffe, Ian A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5256 - 5260
反应条件
1.1: iodine; magnesium / tetrahydrofuran / 0 °C / |Reflux; |Inert atmosphere 1.2: 10 - 20 °C / |Inert atmosphere 2.1: sodium hydroxide / water; methanol / 20 °C / |Inert atmosphere View Scheme
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
potassium chloride in methanol T=24.9°C; different pH values from 298-323 K, different ion strength of KCl solution; Rate constantKineticsMechanism;
参考文献
Chigareva, S. M.; Kuznetsov, S. G.; Vinogradova, N. D.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 12 p. 876 - 881
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 12 p. 1458 - 1462
反应条件
oxygen; copper diacetate in dimethyl sulfoxide T=120°C; 10 h; Sealed tube;
参考文献
Feng, Qiang; Song, Qiuling
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1867 - 1871
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Bodor, Nicholas S.
Patent: US2007/123557 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070123557 A1
反应条件
1: (-)-2-Cyclopentyl-2-hydroxy-2-phenylacetic acid With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=18°C; 2: 3-hydroxy-1-methylpyrrolidine in N,N-dimethyl-formamide T=18 - 60°C; 19 h; Product distribution / selectivity;
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
