您好，欢迎来到魔法化学网！
| CAS号 : | 13220-33-2 |
精确质量 : | 101.08400 |
| 分子式 : | C5H11NO |
logP : | -0.37930 |
| 分子量 : | 101.14700 |
PSA : | 23.47000 |
3-羟基-1-甲基四氢吡咯 | |
1-Methyl-3-pyrrolidinol | |
13220-33-2 | |
C5H11NO | |
101.14700 | |
23.47000 | |
-0.37930 | |
101.08400 |
|
n20/D 1.464(lit.)
|
|
|
无色或淡黄色液体
|
|
|
159 °F
|
|
|
50-52 °C1 mm Hg(lit.)
|
|
|
0.921 g/mL at 25 °C(lit.)
|
|
|
0.132mmHg at 25°C
|
|
|
Stable at room temperature in closed containers under normal storage and handling conditions.
|
|
|
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
|
GHS07 | |
警告 | |
H315; H319; H335 | |
P261; P305 + P351 + P338 | |
|
3
|
|
|
S26-S36/37/39
|
|
|
Xi
|
|
|
R36/37/38
|
|
|
2933990090
|
|
2933990090
|
|
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% | |
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
暂时无法加载合成路线，请稍后刷新重试 |
<p>由1,2,4-丁三醇经氯化、环合而得。<br>1.氯化将丁三醇和冰醋酸加入反应锅内,搅拌加热至100℃左右,通入干燥的氯化氢气体,在90-100℃间反应30h,当尾气开始出现大量氯化氢时,检查反应终点,停通氯化氢。冷却后出料,用饱和碳酸钠溶液洗涤,进行减压蒸馏,收集120-135℃(12.7-13.3kPa)馏分,即得1,4-二氯-2-丁醇,为油状物,收率50-60%。<br>2.环合将1,4-二氯-2-丁醇和甲胺水溶液加入环合锅内,密闭加热至120℃,搅拌反应10h。冷却,加固体氢氧化钠,滤去析出的无机盐。分取油层进行减压蒸馏,收集76-85℃(2.13kPa)馏分,即为成品。水层用苯提取还能得到一部分1-甲基-3-吡咯烷醇。收率60%左右。每吨产品(含量80-90%)需消耗1,4-二氯-2-丁醇(90%)约2330kg,一甲胺(30%)5200kg。</p> | |
<p>用作药品中间体。</p> |
