3'-O-(叔丁基二甲基硅烷基)胸苷合成路线 （共 31 条）
反应条件
1.1: 1.00 g / tetramethylpiperidinium-N-oxide; bis(acetoxy)iodobenzene / acetonitrile; H2O / 2 h / 20 °C 2.1: carbonyl diimidazole / tetrahydrofuran / 1 h / 20 °C 2.2: 1.10 g / tetrahydrofuran; decane / 0.33 h / cooling 3.1: 0.40 g / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / cooling 4.1: 87 percent Chromat. / air / 2-methyl-propan-2-ol; H2O / 3 h / 85 °C View Scheme
参考文献
Montevecchi, Pier Carlo; Manetto, Antonio; Navacchia, Maria Luisa; Chatgilialoglu, Chryssostomos
Tetrahedron, 2004 , vol. 60, # 19 p. 4303 - 4308
反应条件
Bu4NF*2(BF3.Et2O) in acetonitrile 0.166667 h; Ambient temperature;
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1: 4-(N,N-dimethylamino)pyridine 4-DMAP / CH2Cl2 / 6 h 2: aq. HCl / acetonitrile / 6 h View Scheme
参考文献
Davisson, V. Jo; Davis, Darrell R.; Dixit, Vyas M.; Poulter, C. Dale
Journal of Organic Chemistry, 1987 , vol. 52, # 9 p. 1794 - 1801
反应条件
dipotassium peroxodisulfate; RuCl3; potassium hydroxide in water T=20°C; 3.5 h;
参考文献
Debnath, Joy; Dasgupta, Swagata; Pathak, Tanmaya
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 23 p. 8257 - 8263
反应条件
trifluoroacetic acid in dichloromethane; water
T=20°C; 0.75 h;
参考文献
Tronchet, Jean M. J.; Kovacs, Imre; Dilda, Pierre; Seman, Michel; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1927 - 1939
反应条件
sulfonated polystyrene resin in methanol; dichloromethane
0.33 h; Ambient temperature;
参考文献
Patil; Mane; Salunkhe
Synthetic Communications, 1994 , vol. 24, # 17 p. 2423 - 2428
反应条件
formic acid in diethyl ether
T=0°C; 2 h;
参考文献
Magdalena, Julia; Fernandez, Susana; Ferrero, Miguel; Gotor, Vicente
Tetrahedron Letters, 1999 , vol. 40, # 9 p. 1787 - 1790
反应条件
2-(N,N-dimethylamino)-pyridine in pyridine; acetic acid; N,N-dimethyl-formamide
参考文献
University of Rochester
Patent: US5233031 A1, 1993 ;
反应条件
water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate in acetonitrile
T=75°C; 0.5 h;
参考文献
Ramasamy, Kanda S.; Averett, Devron
Synlett, 1999 , # 6 p. 709 - 712
反应条件
in methanol
0.75 h; Irradiation;
参考文献
Pirrung; Fallon; Zhu; Yong Rok Lee
Journal of the American Chemical Society, 2001 , vol. 123, # 16 p. 3638 - 3643
