5-乙酰基噻吩-2-甲酸合成路线 （共 11 条）
反应条件
1: With iso-propylmagnesium bromide in tetrahydrofuran T=-40 - -10°C; Solid phase reaction; 12 h; 2: in dichloromethane T=20°C; Hydrolysis; 0.25 h; Further stages.;
参考文献
Abarbri, Mohamed; Thibonnet, Jerome; Berillon, Laurent; Dehmel, Florian; Rottlaender, Mario; Knochel, Paul
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4618 - 4634
反应条件
hydrogenchloride; n-butyllithium; carbon dioxide in tetrahydrofuran; hexane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5840917 A1, 1998 ;
参考文献
Seitetsu Kagaku Co., Ltd.
Patent: US4792612 A1, 1988 ;
反应条件
PPA T=60 - 80°C; Acylation; Friedel-Crafts acylation; 2 h;
参考文献
Renault, Olivier; Dallemagne, Patrick; Rault, Sylvain
Organic Preparations and Procedures International, 1999 , vol. 31, # 3 p. 324 - 328
反应条件
oxygen; anhydrous cobalt diacetate; sodium bromide in acetic acid T=95°C; 1.5 h; KineticsRate constant;
参考文献
Kazakova, O. A.; Volkov, M. N.; Konstantinov, P. A.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 3 p. 431 - 434
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 3 p. 511 - 514
反应条件
potassium permanganate
参考文献
Gol'dfarb et al.
Ivz. Akad. S.S.S.R. Otd. chim., 1959 , p. 2021,2025; engl. Ausg. S. 1925, 1928
反应条件
hydrazine hydrate; ethylene glycol T=145°C; Erhitzen des Reaktionsgemisches mit Kaliumhydroxid bis auf 193grad;
参考文献
Gol'dfarb et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959 , p. 2021,2023; engl. Ausg. S. 1925, 1927
反应条件
sulfuric acid 72 h; Heating / reflux;
参考文献
Helicon Therapeutics, Inc.
Patent: US2009/62252 A1, 2009 ;
Location in patent: Page/Page column 21; 36 ;
US 20090062252 A1
反应条件
thionyl chloride in tetrahydrofuran; benzene
参考文献
Glaxo Group Limited
Patent: US4316907 A1, 1982 ;
反应条件
sodium carbonate in DMF (N,N-dimethyl-formamide)
T=20°C;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/79791 A1, 2005 ;
Location in patent: Page/Page column 126-127 ;
WO 2005/079791 A1
