4-羟基-1-苯基-1-丁酮合成路线 （共 32 条）
反应条件
1H-imidazole in N,N-dimethyl-formamide T=20°C; 14 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2006/44825 A2, 2006 ;
Location in patent: Page/Page column 62-63 ;
WO 2006/044825 A2
反应条件
2: hydroxylamine 3: 70 percent / sodium hydroxide 4: acetonitrile / Ambient temperature; Irradiation 5: proton View Scheme
参考文献
Saiki, Hiroshi; Mukai, Toshio
Chemistry Letters, 1981 , p. 1561 - 1564
反应条件
1: H2, aq. NH3, NH4Cl / Adams catalyst 2: SOCl2 3: H2O / dioxane / 15 - 25 °C View Scheme
参考文献
Bird,R. et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1973 , p. 1215 - 1220
反应条件
[bis(acetoxy)iodo]benzene; water in hexafluoroisopropyl alcohol
T=20°C; 0.25 h; Inert atmosphere;
参考文献
Fujioka, Hiromichi; Komatsu, Hideyuki; Miyoshi, Akihito; Murai, Kenichi; Kita, Yasuyuki
Tetrahedron Letters, 2011 , vol. 52, # 9 p. 973 - 975
反应条件
1: in diethyl ether; cyclohexane
T=-78°C; 2 h;
2: With water; ammonium chloride in diethyl ether; cyclohexane
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2006/44825 A2, 2006 ;
Location in patent: Page/Page column 62 ;
WO 2006/044825 A2
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; tris(2-methylphenyl)bismuth dichloride in dichloromethane
T=20°C; 0.5 h;
参考文献
Matano, Yoshihiro; Nomura, Hazumi
Angewandte Chemie - International Edition, 2002 , vol. 41, # 16 p. 3028 - 3031
反应条件
water; nickel in tetrahydrofuran
T=20°C; Reduction; 0.666667 h;
参考文献
Barrero, Alejandro F.; Alvarez-Manzaneda; Chahboun, Rachid; Meneses
Synlett, 2000 , # 2 p. 197 - 200
反应条件
Oxonereg;; 2-iodo-3,4,5,6-tetramethylbenzoic acid in water; acetonitrile
T=45°C; 15 h; Green chemistry;
参考文献
Jhulki, Samik; Seth, Saona; Mondal, Manas; Moorthy, Jarugu Narasimha
Tetrahedron, 2014 , vol. 70, # 13 p. 2286 - 2293
反应条件
potassium hydroxide in ethanol; water
T=60°C; 2 h;
参考文献
Wallace, Paul; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2971 - 2978
反应条件
potassium hydroxide in methanol
T=23°C; 12 h;
参考文献
Echavarren, Antonio M.; Perez, Marta; Castano, Ana M.; Cuerva, Juan M.
Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4179 - 4185
