N-(3-氯-4-羟苯基)乙酰苯胺合成路线 （共 17 条）
反应条件
acetic anhydride in water
参考文献
Zeneca Limited
Patent: US5866611 A1, 1999 ;
反应条件
potassium chloride; potassium acetate; acetic acid in water T=25°C; other buffers; effect of pH (3.09 - 7.77); Rate constantProduct distribution;
参考文献
Novak, Michael; Pelecanou, Maria; Roy, Ajit K.; Andronico, Anthony F.; Plourde, Francine M.; et al.
Journal of the American Chemical Society, 1984 , vol. 106, # 19 p. 5623 - 5631
反应条件
potassium chloride in water; acetonitrile T=40°C; Further byproducts given;
参考文献
Novak, Michael; Pelecanou, Maria; Roy, Ajit K.; Andronico, Anthony F.; Plourde, Francine M.; et al.
Journal of the American Chemical Society, 1984 , vol. 106, # 19 p. 5623 - 5631
反应条件
1: acetamide With thionyl chloride in diethyl ether 2: 3-chloro-4-hydroxy-aniline 0.15 h; Heating;
参考文献
Peng, Yanqing; Song, Gonghua; Ding, Fang
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 2021 - 2023
反应条件
acetic anhydride; acetic acid; platinum Hydrogenation;
参考文献
Burckhalter et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1363,1372
Journal of the American Chemical Society, 1950 , vol. 72, p. 1024
反应条件
aluminium trichloride; phenylmethanethiol in dichloromethane 1) 0 deg C, 2) r.t., 3 h; Yield given;
参考文献
Kuehm-Caubere, Catherine; Caubere, Paul; Jamart-Gregoire, Brigitte; Pfeiffer, Bruno; Guardiola-Lemaitre, Beatrice; Manechez, Dominique; Renard, Pierre
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 1 p. 51 - 61
反应条件
1: 89 percent / 4-dimethylaminopyridine, pyridine / diethyl ether; dioxane / 5 h / Ambient temperature 2: AlCl3, PhCH2SH / CH2Cl2 / 1) 0 deg C, 2) r.t., 3 h View Scheme
参考文献
Kuehm-Caubere, Catherine; Caubere, Paul; Jamart-Gregoire, Brigitte; Pfeiffer, Bruno; Guardiola-Lemaitre, Beatrice; Manechez, Dominique; Renard, Pierre
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 1 p. 51 - 61
反应条件
dipotassium hydrogenphosphate; potassium dihydrogenphosphate; potassium chloride in water T=25°C; various buffers; effect of pH (3.09 - 7.82); Rate constantProduct distributionMechanism;
参考文献
Novak, Michael; Pelecanou, Maria; Pollack, Lee
Journal of the American Chemical Society, 1986 , vol. 108, # 1 p. 112 - 120
反应条件
hydrogenchloride; potassium chloride in water; acetonitrile T=30 - 80°C; activation parameters(ΔH++, ΔS++); further reaction conditions; KineticsThermodynamic dataMechanism;
参考文献
Novak, Michael; Pelecanou, Maria; Roy, Ajit K.; Andronico, Anthony F.; Plourde, Francine M.; et al.
Journal of the American Chemical Society, 1984 , vol. 106, # 19 p. 5623 - 5631
反应条件
potassium chloride in water; acetonitrile T=40°C; various potassium halides; Product distributionMechanism;
参考文献
Pelecanou; Novak
Journal of the American Chemical Society, 1985 , vol. 107, # 15 p. 4499 - 4503
