3,3-二乙酰基丙酸甲酯合成路线 （共 10 条）
反应条件
1: acetylacetone With sodium hydride in tetrahydrofuran T=20°C; 0.166667 h; 2: bromoacetic acid methyl ester in tetrahydrofuran T=0 - 20°C;
参考文献
Takahashi; Tanaka; Sakamoto; Imai; Funakoshi; Sakai; Suemune
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 11 p. 1822 - 1825
反应条件
in N,N-dimethyl-formamide; paraffin oil
参考文献
Byk Gulden Lomberg Chemische Fabrik GmbH
Patent: US4146721 A1, 1979 ;
反应条件
potassium carbonate in acetone 1 h; Heating;
参考文献
Clewlow, Paul J.; Jackson, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1925 - 1936
反应条件
in N,N-dimethyl-formamide
参考文献
Boya,M. et al.
Tetrahedron Letters, 1975 , p. 1727 - 1730
参考文献
Jackson, Anthony H.; Supphayen, Damrus
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 277 - 286
参考文献
March
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1900 , vol. 130, p. 1193,1194
Annales de Chimie (Cachan, France), 1902 , vol. <7> 26, p. 308
反应条件
1: Zn dust, sodium acetate, glacial acetic acid / H2O / 1 h / Heating
2: 84 percent / diborane / tetrahydrofuran
3: 94 percent / thionyl chloride, pyridine / CH2Cl2 / 1.5 h / Heating
4: 1.) TFA, 2.) trimethyl orthoformate / 1.) 35 deg C, 10 min, 2.) 0-20 deg C, 2 h
View Scheme
参考文献
Clewlow, Paul J.; Jackson, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1925 - 1936
反应条件
acetic acid
Heating;
参考文献
Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5598 - 5604
反应条件
water; acetic acid; zinc; sodium nitrite
1) 14 deg C then RT overnight; 2) 65 deg C, 4 h then 95 deg C overnight; Yield given. Multistep reaction;
参考文献
Puzicha; Shrout; Lightner
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2117 - 2123
反应条件
potassium carbonate in water
Ambient temperature;
参考文献
Ben Ayed; Amri
Synthetic Communications, 1995 , vol. 25, # 23 p. 3813 - 3819
