4-(氯甲基)-2-甲基-1,3-噻唑合成路线 （共 26 条）
反应条件
potassium carbonate in diethyl ether; water T=20°C; 0.25 h;
参考文献
Chen, Qingqi; Lopez, Rocio Alejandra; Heller, Jonathan Daniel; Morris, Amanda Jean
Patent: US2013/303531 A1, 2013 ;
Location in patent: Paragraph 0107; 0146 ;
参考文献
Novartis AG
Patent: US6350878 B1, 2002 ;
Location in patent: Page column 19 ;
反应条件
4 A molecular sieve in methanol; dichloromethane T=40°C; 24 h;
参考文献
Gasteiger, Johann; Herzig, Christian
Tetrahedron, 1981 , vol. 37, # 15 p. 2607 - 2611
反应条件
zinc(II) chloride in methanol 12 h; Reflux;
参考文献
Cohen, Anita; Crozet, Maxime D.; Rathelot, Pascal; Vanelle, Patrice
Green Chemistry, 2009 , vol. 11, # 11 p. 1736 - 1742
反应条件
phosphorus pentachloride in toluene T=110°C; 0.25 h;
参考文献
Litzinger, Elizabeth A.; Martasek, Pavel; Roman, Linda J.; Silverman, Richard B.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 3185 - 3198
反应条件
1: 65 percent / LiBH4 / ethanol; tetrahydrofuran / 0 - 20 °C 2: thionyl chloride; pyridine / CH2Cl2 / 2 h / -30 - 20 °C View Scheme
参考文献
Zubarovskii,V.M.; Moskaleva,R.N.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 570 - 575,560 - 564
反应条件
thionyl chloride T=65 - 70°C; 0.5 h; Yield given;
参考文献
Marzoni
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 2 p. 577 - 580
反应条件
triethanolamine; ethanol; hydrogen sulfide
参考文献
Liang et al.
Yaoxue Xuebao, 1959 , vol. 7, p. 218,219
Chem.Abstr., 1960 , p. 10996
参考文献
Hooper; Johnson
Journal of the American Chemical Society, 1934 , vol. 56, p. 470
Full Text View citing articles Show Details
Winthrop Chem.Co.
Patent: US2014498 , 1932 ;
反应条件
hydrogen iodide; sodium iodide T=50°C; 3 h;
参考文献
Kajigaeshi, Shoji; Kawano, Yoichi; Fujisaki, Shizuo; Kanemasa, Shuji
Heterocycles, 1985 , vol. 23, # 12 p. 2995 - 2998
