(±)-3,3-二甲基-2-丁胺合成路线 （共 26 条）
反应条件
1: N-(1-phenylethyl)acetamide With triphenyl phosphite; chlorine; triethylamine in dichloromethane T=-30°C; 2: ethylene glycol in dichloromethane T=-30 - 20°C; 3: With water
参考文献
Spaggiari, Alberto; Blaszczak, Larry C.; Prati, Fabio
Organic Letters, 2004 , vol. 6, # 22 p. 3885 - 3888
反应条件
lithium aluminium tetrahydride in diethyl ether Reduction; 30 h; Heating;
参考文献
Erb, Benedicte; Akue, Rufine; Rigo, Benoit; Pirotte, Bernard; Couturier, Daniel
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 253 - 260
反应条件
methanol; ammonia; nickel T=150°C; P=110326 Torr; Hydrogenation;
参考文献
Schwoegler; Adkins
Journal of the American Chemical Society, 1939 , vol. 61, p. 3499,3500
反应条件
ammonium acetate; sodium cyanoborohydride in methanol; water
参考文献
Pfizer Inc.
Patent: US4454328 A1, 1984 ;
反应条件
phosphoric acid T=230 - 240°C;
参考文献
Drake; Kline; Rose
Journal of the American Chemical Society, 1934 , vol. 56, p. 2078
反应条件
nitrobenzene T=160 - 185°C; Kochen des Reaktionsprodukts mit konz.HCl;
参考文献
Ingersoll et al.
Journal of the American Chemical Society, 1936 , vol. 58, p. 1810
反应条件
[{(η5-C5Me5)RhCl}2(μ-Cl)2] in methanol T=70°C; Leuckart-Wallach reaction; 30 h;
参考文献
Kitamura, Masato; Lee, Donghyun; Hayashi, Shinnosuke; Tanaka, Shinji; Yoshimura, Masahiro
Journal of Organic Chemistry, 2002 , vol. 67, # 24 p. 8685 - 8687
反应条件
nickel T=110°C; beim Erhitzen des Reaktionsprodukts mit konz. wss. Salzsaeure;
参考文献
Kost et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951 , p. 150,158
Chem.Abstr., 1951 , p. 10194
反应条件
T=150°C; P=110326 Torr; Hydrogenation;
参考文献
Schwoegler; Adkins
Journal of the American Chemical Society, 1939 , vol. 61, p. 3499,3500
反应条件
hydrogenchloride; iron
参考文献
Markownikow
Chemische Berichte, 1899 , vol. 32, p. 1448
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1899 , vol. 31, p. 527
Chem. Zentralbl., 1899 , vol. 70, # II p. 472
