4-甲氧基-2-硝基苯腈合成路线 （共 24 条）
反应条件
in N,N-dimethyl-formamide T=160°C; 2 h;
参考文献
Loidreau, Yvonnick; Marchand, Pascal; Dubouilh-Benard, Carole; Nourrisson, Marie-Renee; Duflos, Muriel; Loaec, Nadege; Meijer, Laurent; Besson, Thierry
European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 283 - 295
反应条件
potassium iodide; palladium diacetate in ethyl acetate; N,N-dimethyl-formamide
参考文献
American Home Products Corporation
Patent: US5948775 A1, 1999 ;
US 5948775 A
反应条件
1: 2-nitro-4-methoxy-aniline With hydrogenchloride in water 0.333333 h; Heating; 2: With sodium nitrite in water 0.5 h; 3: potassium cyanide With copper (I) cyanide in water 2 h; Heating; Further stages.;
参考文献
Gallou-Dagommer, Isabelle; Gastaud, Philippe; RajanBabu
Organic Letters, 2001 , vol. 3, # 13 p. 2053 - 2056
反应条件
in N,N-dimethyl-formamide T=160°C; 2 h;
参考文献
Queiroz, Maria-Joao R.P.; Calhelha, Ricardo C.; Kirsch, Gilbert
Tetrahedron, 2007 , vol. 63, # 52 p. 13000 - 13005
反应条件
1: 2-nitro-4-methoxy-aniline With hydrogenchloride; sodium nitrite in water T=0°C; 0.5 h; 2: copper (I) cyanide With sodium cyanide in water T=20°C; Sandmeyer reaction; 1 h; Further stages.;
参考文献
Pletnev, Alexandre A.; Tian, Qingping; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9276 - 9287
参考文献
Gen. Aniline and Film Corp.
Patent: US2195076 , 1937 ;
反应条件
water; nickel dichloride
参考文献
Stephen et al.
Journal of the Chemical Society, 1947 , p. 1034,1037
反应条件
in water; tert-butyl alcohol 16 h; Irradiationphotochemical subst. with several nucleophiles; Quantum yieldRate constant;
参考文献
Bunce, Nigel J.; Stephenson, Karen Labonte
Canadian Journal of Chemistry, 1989 , vol. 67, p. 220 - 226
反应条件
T=25°C; other dinitrobenzonitrile, other solvent; Rate constantMechanism;
参考文献
Crampton, Michael R.; Elsegood, Simon E.; Atherton, John H.
Journal of Chemical Research, Miniprint, 1992 , # 6 p. 1371 - 1382
反应条件
1: aqueous sulfuric acid 2: iron (II)-sulfate; aqueous ammonia 4: POCl3; PCl5 View Scheme
参考文献
Chapman; Gibson; Mann
Journal of the Chemical Society, 1947 , p. 890,894
