3-羟基-4,4,4-三氟丁酸乙酯合成路线 （共 20 条）
反应条件
nitrogen; hydrogen; triethylamine; Pt/C
参考文献
Chong, Joshua Anthony; Abdesaken, Fereydon; Spangler, Lori Ann; Roemmele, Renee Caroline; Stephens, Randall Wayne; Nightingale, Peter David; Hartley, David John
Patent: US6307094 B1, 2001 ;
反应条件
sodium tetrahydroborate in diethyl ether 1.) 0-5 deg C, 1 h, 2.) r.t., overnight;
参考文献
Janzen, Edward G.; Zhang, Young-Kang; Arimura, Masana
Journal of Organic Chemistry, 1995 , vol. 60, # 17 p. 5434 - 5440
反应条件
in tetrahydrofuran; water; ethyl acetate
参考文献
TAKASAGO INTERNATIONAL CORPORATION
Patent: US2003/4362 A1, 2003 ;
反应条件
zinc in tetrahydrofuran 2 h; Ambient temperatureultrasonic irradiation;
参考文献
Ishikawa, Nobuo; Koh, Moon Gyu; Kitazume, Tomoya; Choi, Sam Kwon
Journal of Fluorine Chemistry, 1984 , vol. 24, p. 419 - 430
反应条件
hydrogenchloride; sodium borohydride
参考文献
Curators of the University of Missouri; 3M Innovative Properties Company
Patent: US6458865 B2, 2002 ;
反应条件
sulfuric acid 1.) reflux, 6 h, 2.) r.t., 15 h;
参考文献
Binder; Noe; Baumann; Wildburger
Archiv der Pharmazie, 1985 , vol. 318, # 3 p. 243 - 249
反应条件
in water; ethyl acetate
参考文献
TAKASAGO INTERNATIONAL CORPORATION
Patent: US2003/4362 A1, 2003 ;
反应条件
sodium tetrahydroborate
参考文献
Ratier, Max; Pereyre, Michel; Davies, Alwyn G.; Sutcliffe, Roger
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , p. 1907 - 1916
反应条件
sodium tetrahydroborate T=20°C; 0.5 h;
参考文献
Xu, Chengfu; Yuan, Chengye
Tetrahedron, 2005 , vol. 61, # 8 p. 2169 - 2186
参考文献
Jones
Journal of the American Chemical Society, 1948 , vol. 70, p. 143
