2-(甲基硫代)苯甲酸甲酯合成路线 （共 49 条）
反应条件
sodium hydroxide in ethanol
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/67613 A1, 2007 ;
Location in patent: Page/Page column 53 ;
WO 2007/067613 A1
反应条件
MoO2Cl2(dmf)2; glycerol in toluene T=230°C; 0.0833333 h; Microwave irradiationGreen chemistry; TemperatureTimeSolvent; chemoselective reaction;
参考文献
Garcia, Nuria; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Garcia, Daniel; Pedrosa, Maria R.; Arnaiz, Francisco J.; Sanz, Roberto
Green Chemistry, 2013 , vol. 15, # 4 p. 999 - 1005
反应条件
carbon monoxide in methanol T=150°C; P=225018 Torr; 15 h;
参考文献
Bott, Kaspar
Chemische Berichte, 1993 , vol. 126, # 8 p. 1955 - 1956
反应条件
dimethyl sulfate; tetrabutylammomium bromide
参考文献
Hoffmann-La Roche Inc.
Patent: US5270313 A1, 1993 ;
反应条件
sodium methylate in methanol; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US5750549 A1, 1998 ;
US 5750549 A
反应条件
1.1: NaOH / methanol 1.2: HCl / methanol 2.1: H2SO4 View Scheme
参考文献
Aitken, R. Alan; Drysdale, Martin J.; Ferguson, George; Lough, Alan J.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 5 p. 875 - 880
反应条件
ZnF2; copper(I) bromide T=150°C; 36 h; Sealed tubeUnder air;
参考文献
Luo, Fang; Pan, Changduo; Li, Liping; Chen, Fan; Cheng, Jiang
Chemical Communications, 2011 , vol. 47, # 18 p. 5304 - 5306
反应条件
1: 2-amino-benzoic acid methyl ester With tetrafluoroboric acid; acetic acid; isopentyl nitrite in water T=18°C; 0.0833333 h; 2: dimethyl-disulfide With eosin Y disodium salt in dimethyl sulfoxide T=18°C; 12 h; Inert atmosphereUV-irradiationSchlenk technique;
参考文献
Majek, Michal; Von Wangelin, Axel Jacobi
Chemical Communications, 2013 , vol. 49, # 48 p. 5507 - 5509
反应条件
1: 1,1-dioxo-3H-1,2-benzodithiol-3-one; 2-hydroxyethanethiol With water in acetonitrile thiolation; 0.166667 h; 2: diazomethane in diethyl ether T=24°C; Methylation; 0.0833333 h; Further byproducts given;
参考文献
Breydo, Leonid; Gates, Kent S.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 9 p. 885 - 889
反应条件
NaY faujasite T=150°C; 15 h;
参考文献
Selva, Maurizio; Tundo, Pietro
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1464 - 1470
