3-(4-溴苯基)-2-丙酸甲酯合成路线 （共 26 条）
反应条件
(3aS,7aS)-1,3-di-o-tolyl-octahydro-benzoimidazole-2-thione; triethylamine; PdI2 in N,N-dimethyl-formamide T=80°C; Heck cross-coupling; 5 h;
参考文献
Mingji, Dai; Liang, Bo; Wang, Cuihua; You, Zejin; Xiang, Jing; Dong, Guangbin; Chen, Jiahua; Yang, Zhen
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1669 - 1673
反应条件
1: 4-bromo-aniline With tert.-butylnitrite; boron trifluoride diethyl etherate T=-15 - 5°C; 0.583333 h; 2: acrylic acid methyl ester With (R,R)-N,N'-(2-MeC6H4)2-N,N'-(cyclohexane-1,2-diyl)thiourea; palladium diacetate in methanol T=20°C; Heck reaction; 4 h;
参考文献
Dai, Mingji; Liang, Bo; Wang, Cuihua; Chen, Jiahua; Yang, Zhen
Organic Letters, 2004 , vol. 6, # 2 p. 221 - 224
反应条件
trifluoroacetic acid; palladium diacetate; 1,3-bis-(diphenylphosphino)propane in acetone T=70°C; oxidative Heck reaction; 20 h;
参考文献
Ruan, Jiwu; Li, Xinming; Saidi, Ourida; Xiao, Jianliang
Journal of the American Chemical Society, 2008 , vol. 130, # 8 p. 2424 - 2425
反应条件
palladium diacetate in water T=20°C; Heck type reaction; 0.5 h; solid phase reaction;
参考文献
Zarei, Amin; Khazdooz, Leila; Pirisedigh, Azadeh; Hajipour, Abdol R.; Seyedjamali, Hojjat; Aghaei, Hamidreza
Tetrahedron Letters, 2011 , vol. 52, # 35 p. 4554 - 4557
反应条件
triethylamine in tetrahydrofuran arsa-Wittig reaction; 2 h; Refluxsolid phase reaction; stereoselective reaction;
参考文献
Lau, Kelvin C.Y.; Chiu, Pauline
Tetrahedron, 2011 , vol. 67, # 45 p. 8769 - 8774
反应条件
palladium diacetate in methanol T=25°C; Heck cross-coupling; 12 h;
参考文献
Felpin, Francois-Xavier; Miqueu, Karinne; Sotiropoulos, Jean-Marc; Fouquet, Eric; Ibarguren, Oier; Laudien, Julia
Chemistry - A European Journal, 2010 , vol. 16, # 17 p. 5191 - 5204
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Beecham Group p.l.c.
Patent: US4713486 A1, 1987 ;
反应条件
palladium diacetate in ethanol T=20°C; Heck type reaction; 0.25 h; chemoselective reaction;
参考文献
Pirisedigh, Azadeh; Zarei, Amin; Seyedjamali, Hojjat; Khazdooz, Leila; Hajipour, Abdol R.
Monatshefte fur Chemie, 2012 , vol. 143, # 5 p. 791 - 795
反应条件
tri-n-butyl-arsine; zinc in neat (no solvent) T=80°C; 6 h;
参考文献
Shen, Yanchang; Yang, Baozheng; Yuan, Gang
Journal of the Chemical Society, Chemical Communications, 1989 , # 2 p. 144
反应条件
1: carbon monoxide With Cu(OAc)2*2H2O; tetrabutylammomium bromide; palladium dichloride in acetonitrile T=40°C; P=760.051 Torr; 2 h; Inert atmosphere; 2: methanol; 1-bromo-4-ethenylbenzene With oxygen in acetonitrile T=60°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Malkov, Andrei V.; Derrien, Nolwenn; Barlog, Maciej; Kocovsky, Pavel
Chemistry - A European Journal, 2014 , vol. 20, # 16 p. 4542 - 4547
