5,6-二氢-2H-吡喃-2-酮合成路线 （共 59 条）
反应条件
copper(l) iodide
1) hexane, -40 deg C; Yield given. Multistep reaction;
参考文献
Kato, Michiharu; Ouchi, Akihiko; Yoshikoshi, Akira
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 5 p. 1479 - 1486
反应条件
1: vinyl-magnesium bromide With copper(l) iodide in tetrahydrofuran
T=-78°C; 0.25 h; Inert atmosphere;
2: 5,6-dihydro-2H-pyran-2-one in tetrahydrofuran
T=-78°C; 1.5 h; Inert atmosphere;
参考文献
Oderinde, Martins S.; Hunter, Howard N.; Bremner, Stacy W.; Organ, Michael G.
European Journal of Organic Chemistry, 2012 , # 1 p. 175 - 182
反应条件
copper(l) iodide in tetrahydrofuran
T=-78°C;
参考文献
Ito, Hisanaka; Konishi, Masami; Iguchi, Kazuo
Tetrahedron Letters, 2004 , vol. 45, # 9 p. 1941 - 1944
反应条件
nitrogen in tetrahydrofuran; toluene
参考文献
Ciba-Geigy Corporation
Patent: US5025025 A1, 1991 ;
反应条件
1.) CuCN
1.) PhMe, Et2O, 0 deg C, 2 min, 2.) PhMe, Et2O, from -78 deg C to -20 deg C, 45 min; Yield given. Multistep reaction;
参考文献
Main, Alan J.; Bhagwat, Shripad S.; Boswell, Clay; Goldstein, Robert; Gude, Candido; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4366 - 4372
参考文献
Kato, Michiharu; Ouchi, Akihiko; Yoshikoshi, Akira
Chemistry Letters, 1983 , p. 1511 - 1514
反应条件
p-acetamidebenzesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=0°C; Inert atmosphere;
参考文献
Fraile, Jose M.; Le Jeune, Karel; Mayoral, Jose A.; Ravasio, Nicoletta; Zaccheria, Federica
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 26 p. 4327 - 4332
反应条件
1: 65 percent / benzophenone / hexane / 2 h / Irradiation
2: 84 percent / Jones reagent / acetone / 4 h / 0 °C
3: 71 percent / diethyl ether / 0.08 h
4: 1) Mg / 1) ether, 2) ether, -20 deg C, 3 h
5: 71 percent / p-toluenesulfonic acid / toluene / 4 h / Heating
View Scheme
参考文献
Guzman; Mendoza; Diaz
Synthesis, 1981 , vol. No. 12, p. 989 - 991
反应条件
copper(l) iodide in tetrahydrofuran
T=-78°C; 1 h;
参考文献
Tokoroyama, Takashi; Kusaka, Hisashi
Canadian Journal of Chemistry, 1996 , vol. 74, # 12 p. 2487 - 2502
反应条件
diisobutylaluminium hydride in toluene
T=-78°C; 2 h;
参考文献
Martin, Stephen F.; Williamson, Sidney A.; Gist, R. P.; Smith, Karl M.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5170 - 5180
