6,7-二甲氧基-3,4-二氢异喹啉合成路线 （共 75 条）
反应条件
palladium on activated charcoal in decalin T=190°C; 1.5 h;
参考文献
Chemische Berichte, , vol. 117, # 4 p. 1436 - 1454
反应条件
(-)-sparteine in tetrahydrofuran; diethyl ether; cyclohexane T=-76°C; 1 h;
参考文献
Chrzanowska, Maria; Sokolowska, Joanna
Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1435 - 1440
反应条件
1: 89 percent / benzene / 24 h / Ambient temperature 2: 98 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -35 deg C, 30 min, 2.) -30 deg C, 3 h 3: 66 percent / conc. hydrochloric acid / 0.08 h / Heating 4: 76.7 percent / sodium borohydride / ethanol / Ambient temperature View Scheme
参考文献
Kiparissides, Zinovia; Fichtner, Robert H.; Poplawski, Janusz; Nalliah, Bala C.; MacLean, David B.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 2770 - 2779
反应条件
(-)-sparteine in tetrahydrofuran; diethyl ether T=-20°C; 2 h;
参考文献
Chrzanowska, Maria; Sokolowska, Joanna
Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1435 - 1440
反应条件
1.1: 59.7 percent / bromophenol blue; conc. hydrochloric acid / methanol / 0 - 20 °C 2.1: KHMDS / tetrahydrofuran / 3 h / -78 °C 2.2: 557.6 mg / aq. NiCl2 / methanol / 20 °C View Scheme
参考文献
Werner, Frank; Blank, Nancy; Opatz, Till
European Journal of Organic Chemistry, 2007 , # 23 p. 3911 - 3915
反应条件
1: in ethanol T=80°C; 2: With sodium hydroxide; water in dichloromethane
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2008/58261 A1, 2008 ;
Location in patent: Page/Page column 13-14 ;
WO 2008/058261 A1
反应条件
1: palladium/charcoal; decalin 2: H2O 3: phenyl lithium; diethyl ether; dioxane / -20 °C / beim aufeinanderfolgenden Behandeln und mit Veratrylchlorid in Aether und Behandeln des Reaktionsprodukts mit wss.-aethanol.Kalilauge View Scheme
参考文献
Popp; McEwen
Journal of the American Chemical Society, 1957 , vol. 79, p. 3773,3775
反应条件
sodium hydrogencarbonate in dichloromethane; water T=20°C; 1.5 h;
参考文献
Reimann, Eberhard; Grasberger, Fritz
Monatshefte fur Chemie, 2005 , vol. 136, # 2 p. 193 - 209
反应条件
N-benzyl-N,N,N-triethylammonium chloride in dichloromethane; water 0.333333 h; Irradiationultrasound sonication;
参考文献
Ezquerra, Jesus; Alvarez-Builla, Julio
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 917 - 925
反应条件
sodium cyanide in dichloromethane; water 4 h; Ambient temperature;
参考文献
Jackson, Yvette A.; Stephenson, E. Kyle; Cava, Michael P.
Heterocycles, 1993 , vol. 36, # 5 p. 1047 - 1050
