4-[(叔丁氧羰基氨基)甲基]苯甲酸合成路线 （共 22 条）
反应条件
1: With sodium hydrogencarbonate in tetrahydrofuran; water pH=~ 6; 16 h; 2: With hydrogenchloride; water in tetrahydrofuran pH=~ 3;
参考文献
CHROMA THERAPEUTICS LTD.
Patent: WO2008/40934 A1, 2008 ;
Location in patent: Page/Page column 57-58 ;
WO 2008/040934 A1
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=0°C; pH=> 9;
参考文献
CHROMA THERAPEUTICS LTD
Patent: WO2006/117549 A1, 2006 ;
Location in patent: Page/Page column 147 ;
WO 2006/117549 A1
反应条件
1: 4-aminomethyl-benzoic acid ; hydrochloride With sodium hydroxide in ethanol T=10 - 15°C; pH=8; 2: di-tert-butyl dicarbonate in ethanol T=15 - 20°C; 3: With hydrogenchloride in water pH=1;
参考文献
EVOTEC NEUROSCIENCES GMBH; MADDEN, James; HALLETT, David James; PARKES, Alastair; RAOOF, Ali; WANG, Xialou
Patent: WO2010/20556 A1, 2010 ;
Location in patent: Page/Page column 68 ;
WO 2010/020556 A1
反应条件
1: With sodium hydroxide; water in methanol T=60°C; 1 h; 2: With hydrogenchloride in water
参考文献
EP1908752 A1, ;
Page/Page column 50 ;
反应条件
potassium carbonate in water T=20 - 40°C; 3 h; Cooling with ice;
参考文献
EP2439204 A1, ;
Page/Page column 45 ;
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
US5939420 A1, ;
US5958930 A1, ;
US5877178 A1, ;
反应条件
triethylamine; sodium hydroxide in dichloromethane
反应条件
in sodium hydroxide; ethyl acetate
参考文献
Schering Corporation
Patent: US5476847 A1, 1995 ;
US 5476847 A
反应条件
triethylamine in water-1,4-dioxane; water
反应条件
sodium hydroxide; sodium chloride in tetrahydrofuran; hexane
