2-氯-5-三氟甲基苯腈合成路线 （共 20 条）
反应条件
1: 1-amino-2-chloro-5-trifluoromethylbenzene With sulfuric acid in water T=15°C; Sandmeyer Reaction; 0.5 h; Large scale; 2: With sodium nitrite in water; toluene T=3°C; Sandmeyer Reaction; 0.75 h; Large scale; 3: copper (I) cyanide With sodium cyanide; sodium carbonate in n-heptane; water T=65°C; Sandmeyer Reaction; 2 h; Large scale; Temperature;
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 1059 - 1064
反应条件
(i) NaNO2, H2SO4, (ii) aq. ZnCl2, (iii) /BRN= 3587243/, CuCN, aq. NaHCO3, PE; Multistep reaction;
参考文献
Helvetica Chimica Acta, , vol. 45, p. 2226 - 2241
反应条件
pyridine; N,N'-dimethyl-N,N'-propyleneurea; 4,4'-dimethoxy-2,2'-bipyridine; NiI2*3.5H2O; sodium iodide; zinc T=20 - 60°C; 18 h; chemoselective reaction;
参考文献
Everson, Daniel A.; Jones, Brittany A.; Weix, Daniel J.
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6146 - 6159
反应条件
1: With water; sodium hydroxide in tetrahydrofuran T=60°C; 2: With citric acid in ethyl acetate
参考文献
IRM LLC; PETRASSI, Hank Michael James; TULLY, David C.; MASICK, Brian T.; NGUYEN, Bao
Patent: WO2010/120741 A1, 2010 ;
Location in patent: Page/Page column 39 ;
反应条件
(i) NaOMe, DMF, (ii) /BRN= 1912184/, (iii) aq. NaOH, EtOH; Multistep reaction;
参考文献
Lombardino,J.G.; Wiseman,E.H.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 206 - 210
反应条件
1: aq. NaOH / Heating 2: SOCl2 / Heating View Scheme
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
dimethyl sulfate in nitrobenzene; butan-1-ol
参考文献
SmithKline Corporation
Patent: US28939 E1, 1976 ;
反应条件
sodium hydroxide Heating;
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
pyridine; N,N'-dimethyl-N,N'-propyleneurea; 4,4'-dimethoxy-2,2'-bipyridine; NiI2*3.5H2O; sodium iodide; zinc T=20 - 60°C; 18 h; chemoselective reaction;
参考文献
Everson, Daniel A.; Jones, Brittany A.; Weix, Daniel J.
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6146 - 6159
反应条件
pyridine; N,N'-dimethyl-N,N'-propyleneurea; 4,4'-dimethoxy-2,2'-bipyridine; NiI2*3.5H2O; sodium iodide; zinc T=20 - 60°C; 18 h; chemoselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 134, # 14 p. 6146 - 6159
