2-氯-3-甲基苯并(b)噻吩合成路线 （共 37 条）
反应条件
hydrogenchloride in water T=65°C; 1.5 h;
参考文献
Efange, Simon M. N.; Mash, Deborah C.; Khare, Anil B.; Ouyang, Quinjie
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4486 - 4491
反应条件
thionyl chloride in dichloromethane T=0 - 20°C; 3.3 h; regioselective reaction;
参考文献
Standley, Eric A.; Jamison, Timothy F.
Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1585 - 1592
参考文献
Regents of the University of Minnesota; University of Miami
Patent: US5616575 A1, 1997 ;
反应条件
1: sodium tetrahydroborate / methanol / 0.33 h 2: thionyl chloride / dichloromethane / 3.3 h / 0 - 20 °C View Scheme
参考文献
Standley, Eric A.; Jamison, Timothy F.
Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1585 - 1592
反应条件
hydrogenchloride; acetic acid
参考文献
King; Nord
Journal of Organic Chemistry, 1948 , vol. 13, p. 635,637
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Buu-Hoi et al.
Journal of the Chemical Society, 1951 , p. 255
参考文献
Cagniant
Bulletin de la Societe Chimique de France, 1949 , p. 382,387
参考文献
Avakian et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3075
Full Text View citing articles Show Details
Blicke; Sheets
Journal of the American Chemical Society, 1948 , vol. 70, p. 3768,3769
Journal of the American Chemical Society, 1949 , vol. 71, p. 2856,2857
参考文献
King; Nord
Journal of Organic Chemistry, 1948 , vol. 13, p. 635,637
Full Text Show Details
Buu-Hoi et al.
Journal of the Chemical Society, 1951 , p. 255
Full Text Show Details
van Zyl et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2916
反应条件
in dimethyl sulfoxide T=20°C; 18.25 h;
参考文献
MIKANA THERAPEUTICS, INC.
Patent: WO2006/88949 A1, 2006 ;
Location in patent: Page/Page column 170-172 ;
反应条件
N-benzyl-N,N,N-triethylammonium chloride in water T=90 - 95°C; 1 h;
参考文献
Efange, Simon M. N.; Mash, Deborah C.; Khare, Anil B.; Ouyang, Quinjie
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4486 - 4491
