2,6-双（氯甲基）吡啶合成路线 （共 30 条）
反应条件
potassium hydroxide
1.) butanol, RT, 2 h, 2.) butanol, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Kamalov, G. L.; Zakolodyazhnaya, O. V.; Manolova, A. V.; Gavsevich, Yu. V.
J. Gen. Chem. USSR (Engl. Transl.), 1992 , vol. 62, # 3.2 p. 680 - 686,561 - 566
反应条件
in methanol; water
12 h; Ambient temperature;
参考文献
Furukawa, Naomichi; Ogawa, Satoshi; Kawai, Tsutomu; Oae, Shigeru
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 8 p. 1833 - 1838
反应条件
polystyrene supported magnesium anthracene; benzoyl chloride
1.) THF, 2.) THF, RT, 2 h; Multistep reaction;
参考文献
Ancker, Tania R. van den; Harvey, Steven; Raston, Colin L.
Journal of Organometallic Chemistry, 1995 , vol. 502, # 1-2 p. 35 - 46
反应条件
1: 80 percent / Bu4N(HSO4); aq. 50 percent NaOH / toluene / 4 h / Heating
2: 86 percent / HCl gas; NaOH / dioxane / 20 °C
View Scheme
参考文献
Chellini, Andrea; Pagliarin, Roberto; Giovenzanna, Giovanni B.; Palmisano, Giovanni; Sisti, Massimo
Helvetica Chimica Acta, 2000 , vol. 83, # 4 p. 793 - 800
反应条件
1: 82 percent / Bu4N(HSO4); aq. 50 percent NaOH / toluene / Heating
2: 75 percent / HCl gas; NaOH / dioxane / 20 °C
View Scheme
参考文献
Chellini, Andrea; Pagliarin, Roberto; Giovenzanna, Giovanni B.; Palmisano, Giovanni; Sisti, Massimo
Helvetica Chimica Acta, 2000 , vol. 83, # 4 p. 793 - 800
反应条件
1: 2,6-bis-(chloromethyl)pyridine With sulfur; triethylamine in N,N-dimethyl-formamide
2: methyl iodide in N,N-dimethyl-formamide
参考文献
Abrunhosa, Isabelle; Gulea, Mihaela; Levillain, Jocelyne; Masson, Serge
Tetrahedron Asymmetry, 2001 , vol. 12, # 20 p. 2851 - 2859
反应条件
potassium carbonate in acetone
6 h; Reflux;
参考文献
Xu, Lin; He, Meng-Lan; Yang, Hai-Bo; Qian, Xuhong
Dalton Transactions, 2013 , vol. 42, # 23 p. 8218 - 8222
反应条件
in N,N-dimethyl-formamide
T=20°C;
参考文献
BAYER CROPSCIENCE SA
Patent: WO2009/115557 A2, 2009 ;
Location in patent: Page/Page column 90 ;
反应条件
1: NaN3; Na2CO2
View Scheme
参考文献
Jeon, Joong Won; Son, Sang Jun; Yoo, Chang Eun; Hong, In Seok; Suh, Junghun
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2901 - 2910
反应条件
sodium azide; sodium carbonate
参考文献
Jeon, Joong Won; Son, Sang Jun; Yoo, Chang Eun; Hong, In Seok; Suh, Junghun
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2901 - 2910
