5-羟基-2-吡啶甲酸甲酯合成路线 （共 9 条）
反应条件
thionyl chloride T=20°C; 3 h; Reflux;
参考文献
WO2012/76898 A1, ;
Page/Page column 82 ;
WO 2012/076898 A1
反应条件
palladium over carbon
参考文献
US4197302 A1, ;
US4202901 A1, ;
反应条件
1: aqueous HI 2: methanol; HCl View Scheme
参考文献
Chemische Berichte, , vol. 87, p. 13,18
反应条件
1: NaOH; H2O / 220 °C 2: methanol; HCl View Scheme
参考文献
Chemische Berichte, , vol. 87, p. 13,18
反应条件
1: 5-hydroxypyridine-2-carboxylic acid methyl ester With sodium hydride in N,N-dimethyl-formamide 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide 1 h;
参考文献
Brewster, William Kirkland; Klittich, Carla Jean Rasmussen; Balko, Terry William; Breaux, Nneka Tuere; Erickson, William Randal; Hunter, James Edward; Lowe, Christian Thomas; Ricks, Michael John; Siddall, Thomas Lyman; Yerkes, Carla Nanette; Zhu, Yuanming
Patent: US2006/89370 A1, 2006 ;
Location in patent: Page/Page column 33 ;
反应条件
in N-methyl-acetamide; mineral oil
参考文献
Ciba-Geigy Corporation
Patent: US4197302 A1, 1980 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US4202901 A1, 1980 ;
反应条件
water; hydrazine hydrate
参考文献
Scudi; Childress
Journal of Biological Chemistry, 1956 , vol. 218, p. 587
参考文献
The Dow Chemical Company
Patent: US4025333 A1, 1977 ;
