1: iso-butyronitrile With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 0.666667 h; Inert atmosphere; 2: 1-bromo-3-chloro-propane in tetrahydrofuran; hexane T=20°C; Inert atmosphereCooling with ice; regioselective reaction;

lithium diisopropyl amide 1. Et2O; Yield given. Multistep reaction;

(i) PhLi, CaH2, Et2NH, Et2O (ii) /BRN= 1732359/; Multistep reaction;

(i) LiNEt2, (ii) /BRN= 605278/; Multistep reaction;

(i) Na, Et2O, (ii) /BRN= 635662/; Multistep reaction;

1: aq. H2SO4 View Scheme