2,4-二苯基乙酰乙酸乙酯合成路线 （共 26 条）
反应条件
magnesium; isopropyl bromide in tetrahydrofuran 1.) 30 min, reflux, 2.) 0 deg C, room temperature, 3 h;
参考文献
Baretz,B.H.; Turro,N.J.
Journal of the American Chemical Society, 1983 , vol. 105, p. 1309
反应条件
1: phenylpropan-2-one With sodium amide in diethyl ether; toluene 0.5 h; 2: phenylacetic acid, ethyl ester in diethyl ether; toluene 2 h; Reflux;
参考文献
Woon, Esther C.Y.; Sunderland, Peter T.; Paine, Helen A.; Lloyd, Matthew D.; Thompson, Andrew S.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5218 - 5227
反应条件
lithium; 4,4'-di-tert-butylbiphenyl in tetrahydrofuran 36 h; Ambient temperatureIrradiationultrasonic irradiation;
参考文献
Karaman, Rafik; Fry, James L.
Tetrahedron Letters, 1989 , vol. 30, # 37 p. 4935 - 4938
参考文献
Conant; Blatt
Journal of the American Chemical Society, 1929 , vol. 51, p. 1233
反应条件
sodium ethanolate unter Entfernen des entstehenden Aethanols;
参考文献
Wallingford; Homeyer; Jones
Journal of the American Chemical Society, 1941 , vol. 63, p. 2252
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) room temp., 1.5 h, 2.) room temp., 1.5 h;
参考文献
Heinisch, Gottfried; Holzer, Wolfgang; Huber, Thierry
Archiv der Pharmazie (Weinheim, Germany), 1987 , vol. 320, # 12 p. 1267 - 1272
参考文献
Salkind; Baskow
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1914 , vol. 46, p. 477
Chem. Zentralbl., 1914 , vol. 85, # II p. 1268
反应条件
1: concentrated sulfuric acid 2: sodium ethylate View Scheme
参考文献
Volhard
Justus Liebigs Annalen der Chemie, 1897 , vol. 296, p. 29
反应条件
sodium hydride 1.) reflux, 1.5 h; Yield given. Multistep reaction;
参考文献
Khalik, Mervat Mohammed Abdel
Journal of Chemical Research, Miniprint, 1997 , # 6 p. 1377 - 1389
参考文献
Khalik, Mervat Mohammed Abdel
Journal of Chemical Research, Miniprint, 1997 , # 6 p. 1377 - 1389
