2-氨基-3-硝基-6-氯吡啶合成路线 （共 36 条）
反应条件
1: With SnCl2·2H2O in ethyl acetate T=60°C; 1 h; 2: With sodium tetrahydroborate in ethyl acetate T=60°C; 3 h;
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; DAI, Xing; LIU, Hong; HE, Shuwen; DANG, Qung
Patent: WO2013/34048 A1, 2013 ;
Location in patent: Page/Page column 85; 86 ;
反应条件
sodium borohydride; sodium chloride; potassium carbonate in hexane; ethyl acetate
参考文献
Sankyo Company, Limited
Patent: US5624935 A1, 1997 ;
反应条件
triethylamine in isopropyl alcohol 10 h; Reflux;
参考文献
Csuk, Rene; Sommerwerk, Sven; Wiese, Jana; Wagner, Christoph; Siewert, Bianka; Kluge, Ralph; Stroehl, Dieter
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012 , vol. 67, # 12 p. 1297 - 1304
反应条件
1: 80 percent / NaNO2, conc. H2SO4 / 0.5 h / 0 °C 2: 40 percent / Ag2CO3 / toluene / 336 h / Ambient temperature View Scheme
参考文献
Pomel; Rovera; Godard; Marsais; Queguiner
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1995 - 2005
反应条件
sulfuric acid; sodium nitrite T=0°C; 0.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27732 A1, 2009 ;
Location in patent: Page/Page column 70 ;
WO 2009/027732 A1
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=65°C; 0.5 h;
参考文献
Kuehne, Holger; Luebbers, Thomas; Mattei, Patrizio; Maugeais, Cyrille; Pflieger, Philippe; Scalone, Michelangelo
Patent: US2007/185154 A1, 2007 ;
Location in patent: Page/Page column 10 ;
反应条件
sodium hydroxide in ethanol 0.0833333 h; Heating;
参考文献
Huttert, Daniel; Benner, Steven A.
Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9839 - 9842
反应条件
in methanol; ethyl acetate; ethylenediamine; acetonitrile
参考文献
Nuss, John M.; Harrison, Stephen D.; Ring, David B.; Boyce, Rustum S.; Johnson, Kirk; Pfister, Keith B.; Ramurthy, Savithri; Seely, Lynn; Wagman, Allan S.; Desai, Manjo; Levine, Barry H.
Patent: US2002/156087 A1, 2002 ;
US 20020156087 A1
反应条件
in acetonitrile T=75 - 80°C; 12 h;
参考文献
Nuss, John M.; Harrison, Stephen D.; Ring, David B.; Boyce, Rustum S.; Johnson, Kirk; Pfister, Keith B.; Ramurthy, Savithri; Seely, Lynn; Wagman, Allan S.; Desai, Manjo; Levine, Barry H.
Patent: US2002/156087 A1, 2002 ;
US 20020156087 A1
参考文献
Chiron Corporation
Patent: US6417185 B1, 2002 ;
US 6417185 B1
