4,5-二氢-4-氧代呋喃[3,2]吡啶合成路线 （共 22 条）
反应条件
iodine in 1,2-dichloro-benzene T=180°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2100895 A1, 2009 ;
Location in patent: Page/Page column 44 ;
反应条件
(i) ClCO2Et, Et3N, acetone, (ii) aq. NaNO2, (iii) nBu3N, Ph2CH2; Multistep reaction;
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
(i) aq. NaNO2, dioxane, (ii) nBu3N, Ph2CH2; Multistep reaction;
参考文献
New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156
反应条件
iodine in 1,2-dichloro-benzene T=170°C;
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
in diphenylether; dichloromethane Heating; Yield given;
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
1: With triethylamine in acetone Cooling with ice; 2: With sodium azide in water; acetone 1 h; Cooling with ice; 3: With tributyl-amine; diphenylamine T=220°C; 1.5 h;
参考文献
Asagarasu, Akira; Matsui, Teruaki; Hayashi, Hiroyuki; Tamaoki, Satoru; Yamauchi, Yukinao; Sato, Michitaka
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 1 p. 34 - 42
反应条件
1: 78 percent / piperidine; pyridine / 100 °C 2: 68 percent / DPPA; Et3N / tetrahydrofuran / 20 °C 3: toluene / 120 °C 4: I2 / 1,2-dichloro-benzene / 170 °C View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
参考文献
Bourzat,J.-D.; Bisagni,E.
Bulletin de la Societe Chimique de France, 1971 , p. 1727 - 1730
反应条件
1: Et3N 2: H2SO4 View Scheme
参考文献
Bourzat,J.-D.; Bisagni,E.
Bulletin de la Societe Chimique de France, 1971 , p. 1727 - 1730
参考文献
Shiotani, Shunsaku; Taniguchi, Katsunori; Ishida, Toshimasa; In, Yasuko
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 3 p. 647 - 654
