2-乙基-1,3-丙二醇合成路线 （共 12 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 72 h; Reflux;
参考文献
Zimmermann, Nicolas; Pinard, Pierre; Carboni, Bertrand; Gosselin, Pascal; Gaulon-Nourry, Catherine; Dujardin, Gilles; Collet, Sylvain; Lebreton, Jacques; Mathe-Allainmat, Monique
European Journal of Organic Chemistry, 2013 , # 12 p. 2303 - 2315
反应条件
lipase from Pseudomonas Cepacia; sodium chloride; calcium chloride; sodium hydroxide; BSA in water T=37°C; pH=7.5; Enzymatic reaction; optical yield given as percent ee;
参考文献
Mirilashvili, Sima; Chasid-Rubinstein, Naama; Albeck, Amnon
European Journal of Organic Chemistry, 2010 , # 24 p. 4671 - 4686
反应条件
1: in dichloromethane T=-40°C; 5 h; 2: With potassium fluoride; water in dichloromethane T=25°C; 0.5 h;
参考文献
Lewinski, Janusz; Horeglad, Pawel; Tratkiewicz, Ewa; Justyniak, Iwona; Ochal, Zbigniew
Journal of Organometallic Chemistry, 2005 , vol. 690, # 16 p. 3697 - 3699
反应条件
sodium tetrahydroborate in methanol; tert-butyl alcohol 4 h; Heating;
参考文献
Kuznetsov; Alekseeva; Gren'
Russian Journal of General Chemistry, 1997 , vol. 67, # 3 p. 396 - 399
反应条件
T=125°C; P=257428 Torr; Hydrogenation;
参考文献
Adkins; Billica
Journal of the American Chemical Society, 1948 , vol. 70, p. 3121
反应条件
1: 80 percent / diisopropyl ether / 1 h / Ambient temperature; lipase Pseudomonas cepacia 2: 2 M NaOH / Ambient temperature; lipase Pseudomonas cepacia, pH=7.2 3: 60 percent / 4-N,N-dimethylaminopyridine / CH2Cl2 / 48 h / Ambient temperature 4: 90 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature View Scheme
参考文献
Gaucher, Anne; Ollivier, Jean; Marguerite, Jacqueline; Paugam, Renee; Salauen, Jacques
Canadian Journal of Chemistry, 1994 , vol. 72, # 5 p. 1312 - 1327
参考文献
Poldy, Jacqueline; Peakall, Rod; Barrow, Russell A.
Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2446 - 2449
反应条件
1: 64 percent / pyridine / 16 h / Ambient temperature
2: 63 percent / NaH / dioxane / 7 h / Heating
3: 1.) aq.KOH, aq.HCl / 1.) ethanol, reflux, 4 h; 2.) 180°C, 30 min
View Scheme
参考文献
Shafiee, A.; Vossoghi, M.; Savabi, F.; Vlahov, R.; Tarpanov, V.; et al.
Steroids, 1983 , vol. 41, # 3 p. 291 - 308
反应条件
acetate buffer pH 5 in water
T=30°C; 120 h; Gluconobacter roseus IAM 1841;
参考文献
Ohta, Hiromichi; Tetsukawa, Hatsuki; Noto, Naoko
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2400 - 2404
反应条件
1: acetic acid; hydrogen bromide / und Erwaermen des Reaktionsprodukts mit Aethanol und geringen Mengen wss.Bromwasserstoffsaeure
2: aqueous KOH-solution
View Scheme
参考文献
Searles et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 1839,1842
