N-苄氧羰基-L-丝氨酸β-内酯合成路线 （共 13 条）
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=-78°C;
参考文献
Ross, Fiona C.; Botting, Nigel P.; Leeson, Paul D.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 22 p. 2643 - 2646
反应条件
triphenylphosphine in acetonitrile
参考文献
Aventis Pharma Deutschland GmbH
Patent: US2003/119820 A1, 2003 ;
US 20030119820 A1
参考文献
Ueki, Masaaki; Inazu, Toshiyuki
Chemistry Letters, 1982 , p. 45 - 48
反应条件
1.) CuCN 1.) ether, THF, - 23 deg C, 20 min, 2.) THF, -23 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Arnold, Lee D.; Drover, John C. G.; Vederas, John C.
Journal of the American Chemical Society, 1987 , vol. 109, # 15 p. 4649 - 4659
反应条件
Et3SiNH2 in acetonitrile T=50°C; 18 h;
参考文献
Ratemi, Elaref S.; Vederas, John C.
Tetrahedron Letters, 1994 , vol. 35, # 41 p. 7605 - 7608
反应条件
1: 48 h / 40 °C 2: 44 percent / pig liver esterase / acetone; H2O / 38 °C / pH 8 View Scheme
参考文献
Ross, Fiona C.; Botting, Nigel P.; Leeson, Paul D.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 22 p. 2643 - 2646
反应条件
diethylaluminium chloride in hexane; dichloromethane T=20°C; 3 h;
参考文献
Ratemi, Elaref S.; Vederas, John C.
Tetrahedron Letters, 1994 , vol. 35, # 41 p. 7605 - 7608
反应条件
in acetonitrile T=50°C; 24 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/44379 A1, 2008 ;
Location in patent: Page/Page column 63 ;
反应条件
1.) CuCN 1.) ether, THF, - 23 deg C, 20 min, 2.) THF, -23 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Arnold, Lee D.; Drover, John C. G.; Vederas, John C.
Journal of the American Chemical Society, 1987 , vol. 109, # 15 p. 4649 - 4659
反应条件
copper(I) bromide dimethylsulfide complex 1.) THF, 2.) -23 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Arnold, Lee D.; Drover, John C. G.; Vederas, John C.
Journal of the American Chemical Society, 1987 , vol. 109, # 15 p. 4649 - 4659
