3,3-二(4-氯苯基)丙酸合成路线 （共 21 条）
反应条件
1: With AlCl3, aluminium chloride in chlorobenzene
T=0 - 40°C; 1.16667 h;
2: With water in chlorobenzene
参考文献
Allison, Brett; Phuong, Victor K.; Pippel, Marna C.W.; Rabinowitz, Michael H.; Venkatesan, Hariharan
Patent: US2006/69286 A1, 2006 ;
Location in patent: Page/Page column 52 ;
US 20060069286 A1
反应条件
1: With lithium hydroxide; water in tetrahydrofuran; methanol
T=20°C;
2: With hydrogenchloride in water
参考文献
MERCK and CO., INC.
Patent: WO2005/27837 A2, 2005 ;
Location in patent: Page/Page column 52-53 ;
WO 2005/027837 A2
反应条件
in tetrahydrofuran; nitrogen; water; mineral oil
参考文献
Snutch, Terrance P.
Patent: US2003/199523 A1, 2003 ;
US 20030199523 A1
反应条件
iodine in dichloromethane
参考文献
Bristol-Myers Squibb Company
Patent: US6350892 B1, 2002 ;
反应条件
AlCl3, aluminium chloride
T=20°C; 3 h;
参考文献
Ghorai, Prasanta; Kraus, Anja; Keller, Max; Goette, Carsten; Igel, Patrick; Schneider, Erich; Schnell, David; Bernhardt, Guenther; Dove, Stefan; Zabel, Manfred; Elz, Sigurd; Seifert, Roland; Buschauer, Armin
Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7193 - 7204
反应条件
Pd-BaSO4; ethanol
Hydrogenation;
参考文献
Behrens et al.
Journal of Biological Chemistry, 1948 , vol. 175, p. 771,778
Full Text Show Details
Bergmann et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1612,1614
反应条件
1: Behandeln des Reaktionsprodukts mit wss. Natriumcarbonat-Loesung
2: palladium-BaSO4; ethanol / Hydrogenation
View Scheme
参考文献
Bergmann et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1612,1614
反应条件
aluminium trichloride
参考文献
Pfeiffer; Jenning; Stoecker
Justus Liebigs Annalen der Chemie, 1949 , vol. 563, p. 73,85
Full Text Show Details
Fuson; Kozacik; Eaton
Journal of the American Chemical Society, 1933 , vol. 55, p. 3799,3802
反应条件
1: piperidine / toluene / 0.5 h / Heating
2: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min
3: aq. H2SO4, CH3COOH / 24 h / Heating
View Scheme
参考文献
Bogeso
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 935 - 947
反应条件
ethanol; palladium(II)-hydroxide-barium sulfate-catalyst
Hydrogenation;
参考文献
Bergmann et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1612,1614
