2,3-二氢-3-氧代-1,2-苯并异噻唑-2-乙酸乙酯-1,1-二氧化物合成路线 （共 20 条）
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in acetonitrile 3 h; Reflux;
参考文献
CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; CARZANIGA, Laura; LA PORTA, Elena; GUALA, Matilde
Patent: WO2013/57013 A2, 2013 ;
Location in patent: Page/Page column 103; 104 ;
反应条件
in N,N-dimethyl-formamide T=100°C; 8 h;
参考文献
Nikolaev, Vsevolod; Hennig, Lothar; Sieler, Jochim; Rodina, Ludmila; Schulze, Barbel; Nikolaev, Valerij
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 22 p. 4108 - 4116
反应条件
3,3-dimethyldioxirane in acetone T=25°C; Cooling;
参考文献
Sivaramakrishnan, Santhosh; Cummings, Andrea H.; Gates, Kent S.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 444 - 447
反应条件
in N,N-dimethyl-formamide T=120°C; 5 h;
参考文献
Nikolaev, Vsevolod; Hennig, Lothar; Sieler, Jochim; Rodina, Ludmila; Schulze, Barbel; Nikolaev, Valerij
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 22 p. 4108 - 4116
反应条件
potassium fluoride; 1-n-butyl-3-methylimidazolium hexafluorophosphate T=85°C; 1.5 h;
参考文献
Hu, Yi; Chen, Zhen-Chu; Le, Zhang-Gao; Zheng, Qin-Guo
Journal of Chemical Research, 2004 , # 4 p. 276 - 278
反应条件
in N,N-dimethyl-formamide T=120°C;
参考文献
Da Settimo; Primofiore; La Motta; Simorini; Boldrini; Bianchini
Farmaco, 1996 , vol. 51, # 4 p. 261 - 267
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 109 - 111
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 109 - 111
参考文献
Chemische Berichte, , vol. 56, p. 1814
参考文献
Schapira, Celia B.; Perillo, Isabel A.; Lamdan, Samuel
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1281 - 1288
