2-氨基-5-巯基-1,3,4-噻二唑合成路线 （共 50 条）
反应条件
in N,N-dimethyl-formamide 6 h; Reflux;
参考文献
Dubey, Vaibhav; Pathak, Manish; Bhat, Hans R.; Singh, Udaya P.
Chemical Biology and Drug Design, 2012 , vol. 80, # 4 p. 598 - 604
反应条件
carbon disulfide in N-methyl-acetamide; ethanol
参考文献
Olin Corporation
Patent: US4252962 A1, 1981 ;
反应条件
hydrogenchloride in water
参考文献
Heterocycles, , vol. 14, # 2 p. 197 - 200
反应条件
1: 5-amino-2-mercapto-1,3,4-thiadiazole With potassium hydroxide in ethanol 0.166667 h; 2: ethyl bromoacetate in ethanol 2 h;
参考文献
Gao, Yaojun; Samanta, Sanjay; Cui, Taian; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 9 p. 1554 - 1560
反应条件
sodium hydroxide in methanol; water T=20°C; 10 h;
参考文献
Zhao, Jie; Chen, Bao Quan; Shi, Yan Ping; Liu, Yu Ming; Zhao, Hai Chuan; Cheng, Ji
Chinese Chemical Letters, 2012 , vol. 23, # 7 p. 817 - 819
参考文献
Clerici; Pocar; Guido; Loche; Perlini; Brufani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 931 - 936
反应条件
1: 5-amino-2-mercapto-1,3,4-thiadiazole With potassium hydroxide in ethanol 0.166667 h; 2: isopropyl bromide in ethanol 2 h;
参考文献
Gao, Yaojun; Samanta, Sanjay; Cui, Taian; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 9 p. 1554 - 1560
反应条件
in methanol T=70°C; 40 h;
参考文献
Marin; Valls; Berenguer; Alonso; Martinez; Elguero
Farmaco, 1992 , vol. 47, # 1 p. 63 - 75
参考文献
Clerici; Pocar; Guido; Loche; Perlini; Brufani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 931 - 936
