2-氨基-4-甲基苯甲酸合成路线 （共 49 条）
反应条件
1: (i) (diazotization), (ii) aq. Na2S2, (iii) aq. Na2S2O4,(iv) (methylation)
2: (i) SOCl2, (ii) /BRN= 774687/, Mg, (iii) H2SO4, AcOH
View Scheme
参考文献
Ruwet,A.; Renson,M.
Bulletin des Societes Chimiques Belges, 1969 , vol. 78, p. 571 - 582
反应条件
1: T=120°C; 3 h;
2: With ammonia in water
4 h; Reflux;
参考文献
Okano, Masahiko; Mito, Jun; Maruyama, Yasufumi; Masuda, Hirofumi; Niwa, Tomoko; Nakagawa, Shin-ichiro; Nakamura, Yoshitaka; Matsuura, Akira
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 119 - 132
参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1895 , vol. <2> 51, p. 566
反应条件
1: 1.) isoamyl nitrite / 1.) CHCl3, 15 min, reflux; 2.) dioxane 70 deg C
2: HCl / methanol / Heating
View Scheme
参考文献
Gavina, F.; Luis, S. V.; Costero, A. M.
Tetrahedron, 1986 , vol. 42, # 1 p. 155 - 166
参考文献
Mayer; Schulze
Chemische Berichte, 1925 , vol. 58, p. 1467
参考文献
v.Niementowski
Journal fuer Praktische Chemie (Leipzig), 1895 , vol. <2>51, p. 570
参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1895 , vol. <2> 51, p. 570
参考文献
Kulkarni, Shridhar S.; Singh, Satyakam; Shah, Janki R.; Low, Woon-Kai; Talele, Tanaji T.
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 264 - 273
参考文献
Lichtenthaler, Frieder W.; Moser, Alfred
Tetrahedron Letters, 1981 , vol. 22, # 44 p. 4397 - 4400
反应条件
1: 1.) isoamyl nitrite / 1.) CHCl3, 15 min, reflux; 2.) dioxane 70 deg C
2: HCl / methanol / Heating
View Scheme
参考文献
Gavina, F.; Luis, S. V.; Costero, A. M.
Tetrahedron, 1986 , vol. 42, # 1 p. 155 - 166
