Alpha,Alpha-二氟苯乙酸乙酯合成路线 （共 22 条）
反应条件
potassium fluoride; copper(l) iodide in dimethyl sulfoxide T=60°C; 15 h; Inert atmosphere;
参考文献
Amii, Hideki; Fujikawa, Kenichi; Fujioka, Yasutaka; Matsuura, Makoto
Patent: US2012/220795 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
diethylamino-sulfur trifluoride Ambient temperature;
参考文献
Middleton, W. J.; Bingham, E. M.
Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2883 - 2887
反应条件
copper in dimethyl sulfoxide T=55°C; Condensation; 5 h;
参考文献
Sato; Omote; Ando; Kumadaki
Journal of Fluorine Chemistry, 2004 , vol. 125, # 4 p. 509 - 515
反应条件
1: bromo-difluoroacetic acid,ethyl ester With trans-N,N,N′,N'-tetramethylcyclohexane-1,2-diamine; cobalt(II) chloride in tetrahydrofuran T=20°C; 0.0833333 h; Inert atmosphere; 2: C6H5ClZn*C6H16N2 in tetrahydrofuran T=0 - 20°C; 22 h; Inert atmosphere; Reagent/catalystTimeTemperature;
参考文献
Araki, Keisuke; Inoue, Munenori
Tetrahedron, 2013 , vol. 69, # 19 p. 3913 - 3918
反应条件
1: phenylacetyl chloride With pyridine; tin(II) trifluoromethanesulfonate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate); potassium tetrakis(pentafluorophenyl)-borate in acetonitrile T=20°C; 3 h; Inert atmosphere; 2: ethanol in acetonitrile T=0 - 20°C; Inert atmosphere;
参考文献
Bloom, Steven; Scerba, Michael T.; Erb, Jeremy; Lectka, Thomas
Organic Letters, 2011 , vol. 13, # 19 p. 5068 - 5071
反应条件
sodium hydrogencarbonate in ice-water; dichloromethane
参考文献
Merck Sharp and Dohme Limited
Patent: US5981529 A1, 1999 ;
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); potassium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=80°C; 24 h; Schlenk techniqueInert atmosphere; Reagent/catalyst;
参考文献
Feng, Zhang; Min, Qiao-Qiao; Xiao, Yu-Lan; Zhang, Bo; Zhang, Xingang
Angewandte Chemie - International Edition, 2014 , vol. 53, # 6 p. 1669 - 1673
Angew. Chem., 2014 , vol. 126, # 6 p. 1695 - 1699,5
反应条件
IF5-5CH2Cl2 in hexane T=20°C; 2 h;
参考文献
Fukuhara, Tadahito; Hara, Shoji
Synlett, 2009 , # 2 p. 198 - 200
反应条件
triethylamine tris(hydrogen fluoride) in acetonitrile Ambient temperatureelectrochemical oxidation on a platin electrode;
参考文献
Brigaud; Laurent
Tetrahedron Letters, 1990 , vol. 31, # 16 p. 2287 - 2290
反应条件
1: With 2,4,6-trimethyl-pyridine; diphenyl diselenide T=20°C; 0.5 h; 2: 25 h; Photolysis;
参考文献
Murakami, Satoru; Ishii, Hideki; Tajima, Toshiki; Fuchigami, Toshio
Tetrahedron, 2006 , vol. 62, # 15 p. 3761 - 3769
