4-(1-吡咯烷基)苯甲酸合成路线 （共 7 条）
反应条件
copper(II) ferrite; potassium tert-butylate in N,N-dimethyl-formamide T=155°C; 24 h; Inert atmosphere;
参考文献
Panda, Niranjan; Jena, Ashis Kumar; Mohapatra, Sasmita; Rout, Smruti Ranjan
Tetrahedron Letters, 2011 , vol. 52, # 16 p. 1924 - 1927
反应条件
acetic acid T=150°C; Paal-Knorr pyrrole synthesis; 0.166667 h; Microwave irradiation;
参考文献
Liu, Kun; Lu, Hong; Hou, Ling; Qi, Zhi; Teixeira, Catia; Barbault, Florent; Fan, Bo-Tao; Liu, Shuwen; Jiang, Shibo; Xie, Lan
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7843 - 7854
反应条件
1: 1-(para-bromophenyl)-1H-pyrrole With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran T=-75°C; 1 h; 2: carbon dioxide in tetrahydrofuran; diethyl ether T=20°C; Further stages.;
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 9 p. 1039 - 1043
反应条件
1.1: 81 percent / acetic acid 2.1: lithium 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / 1 h / -75 °C 2.2: tetrahydrofuran; diethyl ether / 20 °C View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 9 p. 1039 - 1043
反应条件
hydrogenchloride Reflux;
参考文献
More, Uttam A.; Joshi, Shrinivas D.; Aminabhavi, Tejraj M.; Gadad, Andanappa K.; Nadagouda, Mallikarjuna N.; Kulkarni, Venkatrao H.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 199 - 218
参考文献
More, Uttam A.; Joshi, Shrinivas D.; Aminabhavi, Tejraj M.; Gadad, Andanappa K.; Nadagouda, Mallikarjuna N.; Kulkarni, Venkatrao H.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 199 - 218
反应条件
1: 46 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide / CH2Cl2 / 18 h / Ambient temperature 2: 100 percent / LiAlH4 / tetrahydrofuran / 1.5 h View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
