2-(4-羟基苯氧基)乙酸乙酯合成路线 (共 13 条)
反应条件
sodium hydroxide Heating;
参考文献
Hidaka, Koushi; Kimura, Tooru; Ruben, Adam J.; Uemura, Tsuyoshi; Kamiya, Mami; Kiso, Aiko; Okamoto, Tetsuya; Tsuchiya, Yumi; Hayashi, Yoshio; Freire, Ernesto; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10049 - 10060
反应条件
ethanethiol; AlCl3, aluminium chloride in dichloromethane
T=0°C; 0.666667 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1559422 A1, 2005 ;
Location in patent: Page/Page column 75 ;
EP 1559422 A1
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran
T=20°C; P=2280 Torr; 7 h;
参考文献
Ueno, Hiroshi; Katoh, Susumu; Yokota, Katsuyuki; Hoshi, Jun-ichi; Hayashi, Mikio; Uchida, Itsuo; Aisaka, Kazuo; Hase, Yasunori; Cho, Hidetsura
Bioorganic and medicinal chemistry letters, 2004 , vol. 14, # 16 p. 4281 - 4286
反应条件
sodium ethanolate in ethanol
T=0 - 35°C; 6 h;
参考文献
Liu, Hui; Wang, Hong-Qing; Ding, Ming-Wu; Liu, Zhao-Jie; Xiao, Wen-Jing
Journal of Fluorine Chemistry, 2006 , vol. 127, # 12 p. 1584 - 1590
反应条件
palladium monocarbide in tetrahydrofuran
参考文献
Japan Tobacco Inc.
Patent: US6562828 B1, 2003 ;
US 6562828 B1
参考文献
Fikrat,H.T.; Zenker,N.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 271 - 273
反应条件
sodium ethanolate in ethanol
参考文献
Yu, Zhi-Hua; Shi, De-Qing
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 11 p. 2316 - 2323
反应条件
1: K2CO3 / dimethylformamide; xylene
2: AcOH / Heating
View Scheme
参考文献
Lin, Yun-Loung; Huang, Jian-Lin; Wu, Chung-Shieh; Liu, Hung-Ge; Yang, Ding-Yah
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1709 - 1713
反应条件
1: K2S2O8 / H2O
2: K2CO3 / dimethylformamide; xylene
3: AcOH / Heating
View Scheme
参考文献
Lin, Yun-Loung; Huang, Jian-Lin; Wu, Chung-Shieh; Liu, Hung-Ge; Yang, Ding-Yah
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1709 - 1713
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C
2.1: boron tribromide / dichloromethane / 0 °C
2.2: 20 °C
View Scheme
参考文献
CONNEXIOS LIFE SCIENCES PVT. LTD.; RANGANATH RAO, Jagannath Madanahalli; ARUMUGAM, Nagarajan; ANSARI, Mohd Mudabbir; GUDLA, Chandrasekhar; PACHIYAPPAN, Shanmugam; RAMALINGAM, Manivannan; GEORGE, Jenson; ARUL, George Fernanda; BOMMEGOWDA, Y, Kenchegowda; ANGUPILLAI, Sathesh Kumar; KOTTAMALAI, Ramamoorthy; JIDUGU, Pradeep; RAO, D, Shivanageshwara
Patent: WO2012/11125 A1, 2012 ;
WO 2012/011125 A1