3，4，5-三甲氧基肉桂酸合成路线 （共 41 条）
反应条件
potassium hydroxide 2 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 3 p. 810 - 821
反应条件
1: palladium-barium sulfate; xylene / Hydrogenation 2: pyridine; piperidine View Scheme
参考文献
Chemische Berichte, , vol. 63, p. 3029,3043
反应条件
1: LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature 2: 17 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Ponpipom, Mitree M.; Bugianesi, Robert L.; Brooker, David R.; Yue, Bao-Zhen; Hwang, San-Bao; Shen, Tsung-Ying
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 136 - 142
反应条件
1: 1) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 2) 1N NaOH / 1) dioxane, H2O, 2) dioxane, H2O, reflux 2: K2CO3 / dimethylformamide / 50 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5756735 A1, 1998 ;
US 5756735 A
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5543415 A1, 1996 ;
反应条件
1.1: triethylamine / tetrahydrofuran / 0.75 h / -20 °C 2.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C / |Inert atmosphere 2.2: 1 h / -78 °C View Scheme
参考文献
Rao, Vidadala Ramasubba; Muthenna, Puppala; Shankaraiah, Gundeti; Akileshwari, Chandrasekhar; Babu, Kothapalli Hari; Suresh, Ganji; Babu, Katragadda Suresh; Chandra Kumar, Rotte Sateesh; Prasad, Kothakonda Rajendra; Yadav, Potharaju Ashok; Petrash, J. Mark; Reddy, Geereddy Bhanuprakash; Rao, Janaswamy Madhusudana
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 344 - 361
反应条件
triethylamine in acetonitrile 0.166667 h; microwave irradiation, cooling;
参考文献
Helvetica Chimica Acta, , vol. 88, # 4 p. 811 - 816
反应条件
sulfuric acid 24 h; Reflux;
参考文献
Chemical Biology and Drug Design, , vol. 81, # 3 p. 389 - 398
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 11 p. 2150 - 2154
