2-溴-1,1-二乙氧基乙烷合成路线 （共 272 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; iron(III) chloride in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Guerinot, Amandine; Reymond, Sebastien; Cossy, Janine
Angewandte Chemie - International Edition, 2007 , vol. 46, # 34 p. 6521 - 6524
反应条件
ethanol; potassium hydrosulphide
参考文献
Parham; Wynberg
Org.Synth.Coll., 1963 , vol. Vol.IV, p. 295
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 5 h, 2.) HMPT, room temperature, overnight
2: H2 / Ni-Gr2 / tetrahydrofuran; H2O / 15 h / 50 °C / 22800 Torr
View Scheme
参考文献
Durand,M.H.
Bulletin de la Societe Chimique de France, 1961 , p. 2396 - 2401
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=90°C; 8 h; Inert atmosphere;
参考文献
Kallitsakis, Michael G.; Hadjipavlou-Litina, Dimitra J.; Peperidou, Aikaterini; Litinas, Konstantinos E.
Tetrahedron Letters, 2014 , vol. 55, # 3 p. 650 - 653
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=100°C; 24 h;
参考文献
Dolakova, Petra; Masojidkova, Milena; Holy, Antonin
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2145 - 2160
参考文献
Newbold
Journal of the Chemical Society, 1950 , p. 3346
反应条件
1: dioxane / Heating
2: H2 / Raney-Ni
View Scheme
参考文献
Durand,M.H.
Bulletin de la Societe Chimique de France, 1961 , p. 2396 - 2401
反应条件
(i), (ii) aq. HCl, (iii) NH4OAc, NaBH3CN; Multistep reaction;
参考文献
Varlet,J.-M. et al.
Synthetic Communications, 1978 , vol. 8, p. 335 - 343
反应条件
1: malonic acid dimethyl ester With sodium hydride in N,N-dimethyl-formamide
T=-15°C; 1.166 h; Inert atmosphere;
2: 2-bromoacetaldehyde diethyl acetal in N,N-dimethyl-formamide
T=-15 - 120°C; 12 h; Inert atmosphere;
参考文献
Escalante, Luz; Gonzalez-Rodriguez, Carlos; Varela, Jesus A.; Saa, Carlos
Angewandte Chemie - International Edition, 2012 , vol. 51, # 49 p. 12316 - 12320
Angew. Chem., 2012 , vol. 124, # 49 p. 12482 - 12486,5
反应条件
toluene-4-sulfonic acid
参考文献
Schaefer,H.; Al Azrak,A.
Chemische Berichte, 1972 , vol. 105, p. 2398 - 2418
