(4-氯苯基)-丙酸乙酯合成路线 （共 19 条）
反应条件
1: 1-chloro-4-iodobenzene With copper(l) iodide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=20°C; 0.0833333 h; Inert atmosphere; 2: propynoic acid ethyl ester in tetrahydrofuran T=35°C; Inert atmosphere;
参考文献
Hoffmann-Emery, Fabienne; Puentener, Kurt; Ratni, Hasane
Patent: US2010/152462 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
trifluoromethylsulfonic anhydride; triethylamine; triphenyl-phosphine oxide in 1,2-dichloro-ethane T=85°C; 1.5 h; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad
Patent: WO2012/67664 A1, 2012 ;
Location in patent: Page/Page column 35 ;
反应条件
copper(l) iodide; air; caesium carbonate; silver(l) oxide in dichloromethane T=80°C; Sonogashira type reaction; 36 h;
参考文献
Pan, Changduo; Luo, Fang; Wang, Wenhui; Ye, Zhishi; Cheng, Jiang
Tetrahedron Letters, 2009 , vol. 50, # 35 p. 5044 - 5046
反应条件
1: 1-chloro-4-ethynylbenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 2: chloroformic acid ethyl ester in tetrahydrofuran; hexane T=20°C; 19 h; Inert atmosphere;
参考文献
O'Rourke, Natasha F.; Wulff, Jeremy E.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1292 - 1308
反应条件
Cu(I) 3-methylsalicylate; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide T=45 - 50°C; Sonogashira coupling; 9 h;
参考文献
Chemical Communications, , vol. 47, # 14 p. 4282 - 4284
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C; 2 h; Inert atmosphere; Reagent/catalystSolvent;
参考文献
Aher, Ravindra D.; Gade, Madhuri H.; Reddy, R. Santhosh; Sudalai, Arumugam
Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical and Analytical Chemistry, 2012 , vol. 51, # 9-10 p. 1325 - 1329,5
反应条件
T=500°C; P=0.1 - 1 Torr;
参考文献
Aitken, R. Alan; Horsburg, Caroline E. R.; McCreadie, J. Graeme; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1727 - 1732
反应条件
potassium tert-butylate; sodium amide in tetrahydrofuran T=20°C; 2 h;
参考文献
Synlett, , # 3 p. 443 - 447
反应条件
1: silver(I) acetate / N,N-dimethyl-formamide / 40 h / 70 °C / Darkness 2: Cu(I) 3-methylsalicylate; bis(dibenzylideneacetone)-palladium(0) / N,N-dimethyl-formamide / 9 h / 45 - 50 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 14 p. 4282 - 4284
反应条件
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux 2.1: triethylamine; magnesium chloride / acetonitrile / 3 h / Cooling with ice-salt bath 2.2: 20 °C / Cooling with ice-salt bath 2.3: 1.5 h / Cooling with ice 3.1: trifluoromethylsulfonic anhydride; triethylamine; triphenyl-phosphine oxide / 1,2-dichloro-ethane / 1.5 h / 85 °C / Inert atmosphere View Scheme
