4-二甲氧基甲基-2-丙基磺酰基嘧啶合成路线 （共 8 条）
反应条件
1: 1,1-Dimethoxy-2-oxo-4-dimethylamino-3-butene; thiourea With sodium methylate in methanol T=0 - 80°C; 46 h; 2: propyl bromide in methanol T=50°C; 5 h;
参考文献
Griffin, John; Lanza, Guido; Yu, Jessen
Patent: US2005/261354 A1, 2005 ;
Location in patent: Page/Page column 87 ;
US 20050261354 A1
反应条件
sodium methylate; thiourea in methanol; water; ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US6251914 B1, 2001 ;
反应条件
sodium methylate; thiourea in methanol; water; ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US2003/69243 A1, 2003 ;
US 20030069243 A1
反应条件
1: methylglyoxylate methanol hemiacetal; N,N-dimethyl-formamide dimethyl acetal T=110°C; 3 - 4 h; 2: thiourea With sodium methylate in methanol T=85°C; 3 - 4 h; 3: propyl bromide T=65°C; 1.16667 - 1.25 h; Heating / reflux;
参考文献
SmithKline Beecham Corporation
Patent: US6335340 B1, 2002 ;
Location in patent: Example 23 ;
反应条件
1: 100 °C 2: NaOMe View Scheme
参考文献
Boehm, Jeffrey C.; Bower, Michael J.; Gallagher, Timothy F.; Kassis, Shouki; Johnson, Stephen R.; Adams, Jerry L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1123 - 1126
反应条件
1: NaOMe View Scheme
参考文献
Boehm, Jeffrey C.; Bower, Michael J.; Gallagher, Timothy F.; Kassis, Shouki; Johnson, Stephen R.; Adams, Jerry L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1123 - 1126
参考文献
Boehm, Jeffrey C.; Bower, Michael J.; Gallagher, Timothy F.; Kassis, Shouki; Johnson, Stephen R.; Adams, Jerry L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1123 - 1126
反应条件
in methanol T=60°C; 1 h;
参考文献
Griffin, John; Lanza, Guido; Yu, Jessen
Patent: US2005/261354 A1, 2005 ;
Location in patent: Page/Page column 87; 88 ;
US 20050261354 A1
