4-(苯基甲基)-苯甲酸乙酯合成路线 （共 20 条）
反应条件
sulfuric acid in ethanol
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US5409928 A1, 1995 ;
US 5409928 A
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl acetamide T=90°C; 1 h; chemoselective reaction;
参考文献
Rao, Maddali L. N.; Dhanorkar, Ritesh J.
RSC Advances, 2013 , vol. 3, # 19 p. 6794 - 6798
反应条件
Ni(PCy3)2Cl2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=90°C; Negishi coupling reaction; 8 h; Inert atmosphere;
参考文献
Xie, Lan-Gui; Wang, Zhong-Xia
Angewandte Chemie - International Edition, 2011 , vol. 50, # 21 p. 4901 - 4904
反应条件
diphosphorous tetraiodide in benzene 4 h; Heating;
参考文献
Suzuki, Hitomi; Tani, Hiroyuki; Kubota, Hirohisa; Sato, Naofumi; Tsuji, Junko; Osuka, Atsuhiro
Chemistry Letters, 1983 , p. 247 - 248
参考文献
The Wellcome Foundation Limited
Patent: US5202356 A1, 1993 ;
反应条件
lithium aluminium tetrahydride; diphosphorous tetraiodide in benzene 18 h; Heating;
参考文献
Suzuki, Hitomi; Masuda, Reiko; Kubota, Hirohisa; Osuka, Atsuhiro
Chemistry Letters, 1983 , p. 909 - 910
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [RhCl(η2:η2-cycloocta-1,5-diene)]2 T=80°C; Substitution; 24 h;
参考文献
Hossain, Kabir M.; Takagi, Kentaro
Chemistry Letters, 1999 , # 11 p. 1241 - 1242
反应条件
1.1: 88 percent / DMAP; Et3N / tetrahydrofuran / 4 h / 20 °C 2.1: i-PrMgCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 0.33 h / -20 °C 2.2: CuCl; P(OEt)3 / 1,2-dimethoxy-ethane; tetrahydrofuran / 0.17 h / -15 °C 2.3: 80 percent / tetrabutylammonium iodide / tetrahydrofuran; 1,2-dimethoxy-ethane / 1.5 h / 60 °C View Scheme
参考文献
Kofink, Christiane C.; Knochel, Paul
Organic Letters, 2006 , vol. 8, # 18 p. 4121 - 4124
反应条件
1: N,N-dimethyl-formamide / 24 h / 50 °C / Inert atmosphere 2: Ni(PCy3)2Cl2 / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 8 h / 90 °C / Inert atmosphere View Scheme
参考文献
Xie, Lan-Gui; Wang, Zhong-Xia
Angewandte Chemie - International Edition, 2011 , vol. 50, # 21 p. 4901 - 4904
反应条件
(i) NaOBr, (ii) /BRN= 1718733/; Multistep reaction;
参考文献
Inazu,T.; Yoshino,T.
Bulletin of the Chemical Society of Japan, 1968 , vol. 41, p. 647 - 652
